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Paraquat: The Poison Potion

Paraquat is a commonly used herbicide in India that has lethal consequences even on minimal consumption. The case fatality rate for this poisoning is high and there is dearth of evidence-based recommendation for the treatment of this poison. This review article explores the diagnosis and management...

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Autores principales: Sukumar, Cynthia A, Shanbhag, Vishal, Shastry, Ananthakrishna B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Jaypee Brothers Medical Publishers 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996657/
https://www.ncbi.nlm.nih.gov/pubmed/32021001
http://dx.doi.org/10.5005/jp-journals-10071-23306
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author Sukumar, Cynthia A
Shanbhag, Vishal
Shastry, Ananthakrishna B
author_facet Sukumar, Cynthia A
Shanbhag, Vishal
Shastry, Ananthakrishna B
author_sort Sukumar, Cynthia A
collection PubMed
description Paraquat is a commonly used herbicide in India that has lethal consequences even on minimal consumption. The case fatality rate for this poisoning is high and there is dearth of evidence-based recommendation for the treatment of this poison. This review article explores the diagnosis and management of paraquat poisoning with an emphasis on recent advances in treatment. Though immunosuppressants and antioxidants are conventionally used, there is a gap in evidence to prove survival benefit of these treatment regimens. There are also some data showing the use of hemoperfusion (with toxin-specific cartridges) as an early intervention, i.e., within 4 hours of exposure to the poison. The recent drug, Edaravone, has also shown promise in the prevention of renal and hepatic injury in paraquat poisoning. Though it did not reduce pulmonary fibrosis in patients with paraquat poisoning, it delays the generation and development of pulmonary fibrosis. However, there is a need for more clinical and experimental studies to validate its use in paraquat poisoning. HOW TO CITE THIS ARTICLE: Sukumar CA, Shanbhag V, Shastry AB. Paraquat: The Poison Potion. Indian J Crit Care Med 2019;23(Suppl 4):S263–S266.
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spelling pubmed-69966572020-02-04 Paraquat: The Poison Potion Sukumar, Cynthia A Shanbhag, Vishal Shastry, Ananthakrishna B Indian J Crit Care Med Invited Article Paraquat is a commonly used herbicide in India that has lethal consequences even on minimal consumption. The case fatality rate for this poisoning is high and there is dearth of evidence-based recommendation for the treatment of this poison. This review article explores the diagnosis and management of paraquat poisoning with an emphasis on recent advances in treatment. Though immunosuppressants and antioxidants are conventionally used, there is a gap in evidence to prove survival benefit of these treatment regimens. There are also some data showing the use of hemoperfusion (with toxin-specific cartridges) as an early intervention, i.e., within 4 hours of exposure to the poison. The recent drug, Edaravone, has also shown promise in the prevention of renal and hepatic injury in paraquat poisoning. Though it did not reduce pulmonary fibrosis in patients with paraquat poisoning, it delays the generation and development of pulmonary fibrosis. However, there is a need for more clinical and experimental studies to validate its use in paraquat poisoning. HOW TO CITE THIS ARTICLE: Sukumar CA, Shanbhag V, Shastry AB. Paraquat: The Poison Potion. Indian J Crit Care Med 2019;23(Suppl 4):S263–S266. Jaypee Brothers Medical Publishers 2019-12 /pmc/articles/PMC6996657/ /pubmed/32021001 http://dx.doi.org/10.5005/jp-journals-10071-23306 Text en Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd. © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Invited Article
Sukumar, Cynthia A
Shanbhag, Vishal
Shastry, Ananthakrishna B
Paraquat: The Poison Potion
title Paraquat: The Poison Potion
title_full Paraquat: The Poison Potion
title_fullStr Paraquat: The Poison Potion
title_full_unstemmed Paraquat: The Poison Potion
title_short Paraquat: The Poison Potion
title_sort paraquat: the poison potion
topic Invited Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996657/
https://www.ncbi.nlm.nih.gov/pubmed/32021001
http://dx.doi.org/10.5005/jp-journals-10071-23306
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