Cell-free hemoglobin increases inflammation, lung apoptosis, and microvascular permeability in murine polymicrobial sepsis

Increased endothelial permeability is central to the pathogenesis of sepsis and leads to organ dysfunction and death but the endogenous mechanisms that drive increased endothelial permeability are not completely understood. We previously reported that cell-free hemoglobin (CFH), elevated in 80% of p...

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Detalles Bibliográficos
Autores principales: Meegan, Jamie E., Shaver, Ciara M., Putz, Nathan D., Jesse, Jordan J., Landstreet, Stuart R., Lee, Han Noo Ri, Sidorova, Tatiana N., McNeil, J. Brennan, Wynn, James L., Cheung-Flynn, Joyce, Komalavilas, Padmini, Brophy, Colleen M., Ware, Lorraine B., Bastarache, Julie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996826/
https://www.ncbi.nlm.nih.gov/pubmed/32012200
http://dx.doi.org/10.1371/journal.pone.0228727

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