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The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer

A hallmark of Spemann organizer function is its expression of Wnt antagonists that regulate axial embryonic patterning. Here we identify the tumor suppressor Protein tyrosine phosphatase receptor-type kappa (PTPRK), as a Wnt inhibitor in human cancer cells and in the Spemann organizer of Xenopus emb...

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Detalles Bibliográficos
Autores principales:	Chang, Ling-Shih, Kim, Minseong, Glinka, Andrey, Reinhard, Carmen, Niehrs, Christof
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996932/ https://www.ncbi.nlm.nih.gov/pubmed/31934854 http://dx.doi.org/10.7554/eLife.51248

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