Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis

Mutations in lamin A (LMNA) are responsible for a variety of human dystrophic and metabolic diseases. Here, we created a mouse model in which progerin, the lamin A mutant protein that causes Hutchinson–Gilford progeria syndrome (HGPS), can be inducibly overexpressed. Muscle‐specific overexpression o...

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Detalles Bibliográficos
Autores principales: Wang, Wan‐Ping, Wang, Jing‐Ya, Lin, Wen‐Hsin, Kao, Cheng‐Heng, Hung, Ming‐Chun, Teng, Yuan‐Chi, Tsai, Ting‐Fen, Chi, Ya‐Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996945/
https://www.ncbi.nlm.nih.gov/pubmed/31833196
http://dx.doi.org/10.1111/acel.13090

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