Cargando…

A small molecule transcription factor EB activator ameliorates beta‐amyloid precursor protein and Tau pathology in Alzheimer's disease models

Accumulating studies have suggested that targeting transcription factor EB (TFEB), an essential regulator of autophagy‐lysosomal pathway (ALP), is promising for the treatment of neurodegenerative disorders, including Alzheimer's disease (AD). However, potent and specific small molecule TFEB act...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Ju‐Xian, Malampati, Sandeep, Zeng, Yu, Durairajan, Siva Sundara Kumar, Yang, Chuan‐Bin, Tong, Benjamin Chun‐Kit, Iyaswamy, Ashok, Shang, Wen‐Bin, Sreenivasmurthy, Sravan Gopalkrishnashetty, Zhu, Zhou, Cheung, King‐Ho, Lu, Jia‐Hong, Tang, Chunzhi, Xu, Nenggui, Li, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996953/ https://www.ncbi.nlm.nih.gov/pubmed/31858697 http://dx.doi.org/10.1111/acel.13069

Ejemplares similares

Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer’s disease and tauopathy models
por: Selvarasu, Karthikeyan, et al.
Publicado: (2022)

A modified formulation of Huanglian-Jie-Du-Tang reduces memory impairments and β-amyloid plaques in a triple transgenic mouse model of Alzheimer’s disease
por: Durairajan, Siva Sundara Kumar, et al.
Publicado: (2017)

A Curcumin Derivative Activates TFEB and Protects Against Parkinsonian Neurotoxicity in Vitro
por: Wang, Ziying, et al.
Publicado: (2020)

Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies
por: Tong, Benjamin Chun-Kit, et al.
Publicado: (2022)

Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer’s disease therapy
por: Sreenivasmurthy, Sravan Gopalkrishnashetty, et al.
Publicado: (2022)

Targeting Aggrephagy for the Treatment of Alzheimer’s Disease
por: Malampati, Sandeep, et al.
Publicado: (2020)

Neurogenic Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer’s Disease
por: Sreenivasmurthy, Sravan Gopalkrishnashetty, et al.
Publicado: (2017)

Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy
por: Yang, Chuanbin, et al.
Publicado: (2022)

Real-Time Detection and Visualization of Amyloid-β Aggregates Induced by Hydrogen Peroxide in Cell and Mouse Models of Alzheimer’s Disease
por: Wang, Xueli, et al.
Publicado: (2022)

Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models
por: Iyaswamy, Ashok, et al.
Publicado: (2022)

Corynoxine isomers decrease levels of amyloid-β peptide and amyloid-β precursor protein by promoting autophagy and lysosome biogenesis
por: Durairajan, Siva Sundara Kumar, et al.
Publicado: (2013)

Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s Disease
por: Zhu, Zhou, et al.
Publicado: (2019)

Mechanistic Insights into Selective Autophagy Subtypes in Alzheimer’s Disease
por: Guan, Xinjie, et al.
Publicado: (2022)

A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38
por: Yang, Chuanbin, et al.
Publicado: (2020)

Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer’s Disease
por: Iyaswamy, A., et al.
Publicado: (2020)

Effects of Huanglian-Jie-Du-Tang and Its Modified Formula on the Modulation of Amyloid-β Precursor Protein Processing in Alzheimer's Disease Models
por: Durairajan, Siva Sundara Kumar, et al.
Publicado: (2014)

Novel Insight into Functions of Transcription Factor EB (TFEB) in Alzheimer’s Disease and Parkinson’s Disease
por: Yang, Jing, et al.
Publicado: (2023)

Amyloid Precursor Protein and Tau Peptides Linked Together Ameliorate Loss of Cognition in an Alzheimer’s Disease Animal Model
por: Maron, Ruth, et al.
Publicado: (2023)

Recent Updates on Mouse Models for Human Immunodeficiency, Influenza, and Dengue Viral Infections
por: Krishnakumar, Vinodhini, et al.
Publicado: (2019)

Identification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells
por: Hindupur, Sravanth K, et al.
Publicado: (2014)

Systematic Review on the Efficacy and Safety of Herbal Medicines for Vascular Dementia
por: Man, Sui Cheung, et al.
Publicado: (2012)

Animal models for SARS-CoV-2 and SARS-CoV-1 pathogenesis, transmission and therapeutic evaluation
por: Saravanan, Udhaya Bharathy, et al.
Publicado: (2022)

Klotho an Autophagy Stimulator as a Potential Therapeutic Target for Alzheimer’s Disease: A Review
por: Fung, Tsz Yan, et al.
Publicado: (2022)

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
por: Polito, Vinicia A, et al.
Publicado: (2014)

Activated PPARγ Abrogates Misprocessing of Amyloid Precursor Protein, Tau Missorting and Synaptotoxicity
por: Moosecker, Susanne, et al.
Publicado: (2019)

Tau post-translational modifications in wildtype and human amyloid precursor protein transgenic mice
por: Morris, Meaghan, et al.
Publicado: (2015)

Salvianolic Acid B Inhibits Hydrogen Peroxide-Induced Endothelial Cell Apoptosis through Regulating PI3K/Akt Signaling
por: Liu, Chen-Li, et al.
Publicado: (2007)

Corrigendum: Activated PPARγ Abrogates Misprocessing of Amyloid Precursor Protein, Tau Missorting and Synaptotoxicity
por: Moosecker, Susanne, et al.
Publicado: (2020)

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
por: Pandey, Poomy, et al.
Publicado: (2016)

The amyloid precursor protein: beyond amyloid
por: Zheng, Hui, et al.
Publicado: (2006)

A Novel Species of Penicillium With Inhibitory Effects Against Pyricularia oryzae and Fungal Pathogens Inducing Citrus Diseases
por: Liang, Li-Juan, et al.
Publicado: (2021)

Model Hirano Bodies Protect against Tau-Independent and Tau-Dependent Cell Death Initiated by the Amyloid Precursor Protein Intracellular Domain
por: Furgerson, Matthew, et al.
Publicado: (2012)

Optical induction of autophagy via Transcription factor EB (TFEB) reduces pathological tau in neurons
por: Binder, Jessica L., et al.
Publicado: (2020)

Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson’s disease
por: Liu, Liang-Feng, et al.
Publicado: (2015)

Soluble P‐tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau
por: Mattsson‐Carlgren, Niklas, et al.
Publicado: (2021)

A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity
por: Rush, Travis, et al.
Publicado: (2019)

Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain
por: Spears, William, et al.
Publicado: (2014)

Subacute Changes in Cleavage Processing of Amyloid Precursor Protein and Tau following Penetrating Traumatic Brain Injury
por: Cartagena, Casandra M., et al.
Publicado: (2016)

Neurodevelopmental disorders and microcephaly: how apoptosis, the cell cycle, tau and amyloid-β precursor protein APPly
por: Sokol, Deborah K., et al.
Publicado: (2023)

Prediction of Cerebral Amyloid Pathology Based on Plasma Amyloid and Tau Related Markers
por: Chen, Ting-Bin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3c56ce40m6da6ms86llski4nei