Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment

Even in healthy aging, cardiac morbidity and mortality increase with age in both mice and humans. These effects include a decline in diastolic function, left ventricular hypertrophy, metabolic substrate shifts, and alterations in the cardiac proteome. Previous work from our laboratory indicated that...

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Detalles Bibliográficos
Autores principales: Quarles, Ellen, Basisty, Nathan, Chiao, Ying Ann, Merrihew, Gennifer, Gu, Haiwei, Sweetwyne, Mariya T., Fredrickson, Jeanne, Nguyen, Ngoc‐Han, Razumova, Maria, Kooiker, Kristina, Moussavi‐Harami, Farid, Regnier, Michael, Quarles, Christopher, MacCoss, Michael, Rabinovitch, Peter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996961/
https://www.ncbi.nlm.nih.gov/pubmed/31823466
http://dx.doi.org/10.1111/acel.13086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996961/
https://www.ncbi.nlm.nih.gov/pubmed/31823466
http://dx.doi.org/10.1111/acel.13086

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