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Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma

Effectors from the immune system can modulate the course and possibly the early development of gliomas. We, therefore, hypothesized that autoimmune diseases associated with increased immune‐surveillance may also modulate the risk of human glioma. To test this hypothesis, we used data from the well‐v...

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Autores principales: Anssar, Tareq M., Leitzmann, Michael F., Linker, Ralf A., Meier, Christoph, Becker, Claudia, Jick, Susan, Sahm, Katharina, Platten, Michael, Hau, Peter, Seliger, Corinna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997055/
https://www.ncbi.nlm.nih.gov/pubmed/31821741
http://dx.doi.org/10.1002/cam4.2767
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author Anssar, Tareq M.
Leitzmann, Michael F.
Linker, Ralf A.
Meier, Christoph
Becker, Claudia
Jick, Susan
Sahm, Katharina
Platten, Michael
Hau, Peter
Seliger, Corinna
author_facet Anssar, Tareq M.
Leitzmann, Michael F.
Linker, Ralf A.
Meier, Christoph
Becker, Claudia
Jick, Susan
Sahm, Katharina
Platten, Michael
Hau, Peter
Seliger, Corinna
author_sort Anssar, Tareq M.
collection PubMed
description Effectors from the immune system can modulate the course and possibly the early development of gliomas. We, therefore, hypothesized that autoimmune diseases associated with increased immune‐surveillance may also modulate the risk of human glioma. To test this hypothesis, we used data from the well‐validated Clinical Practice Research Datalink (CPRD) GOLD from the UK to analyze the association of immune‐related disorders or use of immunosuppressive drugs and the risk of glioma. We identified 3112 incident glioma cases diagnosed between 1995 and 2017. We randomly selected up to 10 controls, matching them to glioma cases on age, sex, index date, general practice, and number of years of active history in the database prior to the index date. We performed conditional logistic regression analyses to estimate Odds Ratios (ORs) of glioma among those exposed to allergies, autoimmune diseases, and immunosuppressive drugs. Overall, we found no materially altered association between a history of any autoimmune disease (OR 0.98, 95% CI 0.86‐1.11), allergy (OR 0.97, 95% CI 0.89‐1.05), or use of immunosuppressive drugs and the risk of glioma. However, subgroup analyses among younger patients found a statistically significant increased risk of glioma in patients with a history of inflammatory bowel disease (IBD) (OR 2.59, 95% CI 1.31‐5.12). There was also an inverse association between asthma and risk of glioma in patients with longer survival (OR 0.73, 95% CI 0.58‐0.91) and between long‐term duration diabetes and risk of glioma (OR 0.71, 95% CI 0.53‐0.96).
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spelling pubmed-69970552020-02-05 Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma Anssar, Tareq M. Leitzmann, Michael F. Linker, Ralf A. Meier, Christoph Becker, Claudia Jick, Susan Sahm, Katharina Platten, Michael Hau, Peter Seliger, Corinna Cancer Med Cancer Prevention Effectors from the immune system can modulate the course and possibly the early development of gliomas. We, therefore, hypothesized that autoimmune diseases associated with increased immune‐surveillance may also modulate the risk of human glioma. To test this hypothesis, we used data from the well‐validated Clinical Practice Research Datalink (CPRD) GOLD from the UK to analyze the association of immune‐related disorders or use of immunosuppressive drugs and the risk of glioma. We identified 3112 incident glioma cases diagnosed between 1995 and 2017. We randomly selected up to 10 controls, matching them to glioma cases on age, sex, index date, general practice, and number of years of active history in the database prior to the index date. We performed conditional logistic regression analyses to estimate Odds Ratios (ORs) of glioma among those exposed to allergies, autoimmune diseases, and immunosuppressive drugs. Overall, we found no materially altered association between a history of any autoimmune disease (OR 0.98, 95% CI 0.86‐1.11), allergy (OR 0.97, 95% CI 0.89‐1.05), or use of immunosuppressive drugs and the risk of glioma. However, subgroup analyses among younger patients found a statistically significant increased risk of glioma in patients with a history of inflammatory bowel disease (IBD) (OR 2.59, 95% CI 1.31‐5.12). There was also an inverse association between asthma and risk of glioma in patients with longer survival (OR 0.73, 95% CI 0.58‐0.91) and between long‐term duration diabetes and risk of glioma (OR 0.71, 95% CI 0.53‐0.96). John Wiley and Sons Inc. 2019-12-10 /pmc/articles/PMC6997055/ /pubmed/31821741 http://dx.doi.org/10.1002/cam4.2767 Text en © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Prevention
Anssar, Tareq M.
Leitzmann, Michael F.
Linker, Ralf A.
Meier, Christoph
Becker, Claudia
Jick, Susan
Sahm, Katharina
Platten, Michael
Hau, Peter
Seliger, Corinna
Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma
title Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma
title_full Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma
title_fullStr Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma
title_full_unstemmed Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma
title_short Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma
title_sort autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma
topic Cancer Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997055/
https://www.ncbi.nlm.nih.gov/pubmed/31821741
http://dx.doi.org/10.1002/cam4.2767
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