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Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production
Overproduction of polyketides has been a challenge for metabolic engineering for decades. However, recent studies have demonstrated that in both native host and heterologous host, engineering β -oxidation pathways can lead to dramatic improvement of polyketide production.
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
KeAi Publishing
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997112/ https://www.ncbi.nlm.nih.gov/pubmed/32042931 http://dx.doi.org/10.1016/j.synbio.2020.01.002 |
| _version_ | 1783493624373182464 |
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| author | Wang, Bin Zhao, Huimin |
| author_facet | Wang, Bin Zhao, Huimin |
| author_sort | Wang, Bin |
| collection | PubMed |
| description | Overproduction of polyketides has been a challenge for metabolic engineering for decades. However, recent studies have demonstrated that in both native host and heterologous host, engineering β -oxidation pathways can lead to dramatic improvement of polyketide production. |
| format | Online Article Text |
| id | pubmed-6997112 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | KeAi Publishing |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-69971122020-02-10 Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production Wang, Bin Zhao, Huimin Synth Syst Biotechnol Article Overproduction of polyketides has been a challenge for metabolic engineering for decades. However, recent studies have demonstrated that in both native host and heterologous host, engineering β -oxidation pathways can lead to dramatic improvement of polyketide production. KeAi Publishing 2020-02-01 /pmc/articles/PMC6997112/ /pubmed/32042931 http://dx.doi.org/10.1016/j.synbio.2020.01.002 Text en © 2020 Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Article Wang, Bin Zhao, Huimin Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production |
| title | Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production |
| title_full | Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production |
| title_fullStr | Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production |
| title_full_unstemmed | Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production |
| title_short | Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production |
| title_sort | unleashing the power of energy storage: engineering β-oxidation pathways for polyketide production |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997112/ https://www.ncbi.nlm.nih.gov/pubmed/32042931 http://dx.doi.org/10.1016/j.synbio.2020.01.002 |
| work_keys_str_mv | AT wangbin unleashingthepowerofenergystorageengineeringboxidationpathwaysforpolyketideproduction AT zhaohuimin unleashingthepowerofenergystorageengineeringboxidationpathwaysforpolyketideproduction |