Kawasaki Disease Following Severe Sunburn Injury

Background: Although an etiology of Kawasaki disease (KD) is unknown, an aberrant innate immune system in predisposed individuals has been proposed to play a key role in the development of KD vasculitis. Various etiological pathogens have been proposed as the trigger of KD and a scaled injury preced...

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Autores principales: Okada, Seigo, Hashimoto, Shintaro, Miyake, Akiko, Okada, Yusuke, Hirano, Reiji, Fukunaga, Shinnosuke, Ishikawa, Yuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997125/
https://www.ncbi.nlm.nih.gov/pubmed/32047731
http://dx.doi.org/10.3389/fped.2020.00006
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author Okada, Seigo
Hashimoto, Shintaro
Miyake, Akiko
Okada, Yusuke
Hirano, Reiji
Fukunaga, Shinnosuke
Ishikawa, Yuichi
author_facet Okada, Seigo
Hashimoto, Shintaro
Miyake, Akiko
Okada, Yusuke
Hirano, Reiji
Fukunaga, Shinnosuke
Ishikawa, Yuichi
author_sort Okada, Seigo
collection PubMed
description Background: Although an etiology of Kawasaki disease (KD) is unknown, an aberrant innate immune system in predisposed individuals has been proposed to play a key role in the development of KD vasculitis. Various etiological pathogens have been proposed as the trigger of KD and a scaled injury preceding symptom onset has been reported as one of them. Here, we report a 17-month-old Japanese female who was hospitalized due to high fever lasting for 4 days with infection ruled out as a cause. On admission, she displayed severe sunburn all over her body following a prolonged period of outdoor play 5 days ago. On the 5 day of illness, she developed complete KD. Serum levels of high mobility group box 1, a representative for damage-associated molecular patterns (DAMPs), were elevated during acute phase and continued to decrease during subacute phase. This unique course suggested the inflammatory process of KD involving innate immunity via DAMPs.
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spelling pubmed-69971252020-02-11 Kawasaki Disease Following Severe Sunburn Injury Okada, Seigo Hashimoto, Shintaro Miyake, Akiko Okada, Yusuke Hirano, Reiji Fukunaga, Shinnosuke Ishikawa, Yuichi Front Pediatr Pediatrics Background: Although an etiology of Kawasaki disease (KD) is unknown, an aberrant innate immune system in predisposed individuals has been proposed to play a key role in the development of KD vasculitis. Various etiological pathogens have been proposed as the trigger of KD and a scaled injury preceding symptom onset has been reported as one of them. Here, we report a 17-month-old Japanese female who was hospitalized due to high fever lasting for 4 days with infection ruled out as a cause. On admission, she displayed severe sunburn all over her body following a prolonged period of outdoor play 5 days ago. On the 5 day of illness, she developed complete KD. Serum levels of high mobility group box 1, a representative for damage-associated molecular patterns (DAMPs), were elevated during acute phase and continued to decrease during subacute phase. This unique course suggested the inflammatory process of KD involving innate immunity via DAMPs. Frontiers Media S.A. 2020-01-28 /pmc/articles/PMC6997125/ /pubmed/32047731 http://dx.doi.org/10.3389/fped.2020.00006 Text en Copyright © 2020 Okada, Hashimoto, Miyake, Okada, Hirano, Fukunaga and Ishikawa. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Okada, Seigo
Hashimoto, Shintaro
Miyake, Akiko
Okada, Yusuke
Hirano, Reiji
Fukunaga, Shinnosuke
Ishikawa, Yuichi
Kawasaki Disease Following Severe Sunburn Injury
title Kawasaki Disease Following Severe Sunburn Injury
title_full Kawasaki Disease Following Severe Sunburn Injury
title_fullStr Kawasaki Disease Following Severe Sunburn Injury
title_full_unstemmed Kawasaki Disease Following Severe Sunburn Injury
title_short Kawasaki Disease Following Severe Sunburn Injury
title_sort kawasaki disease following severe sunburn injury
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997125/
https://www.ncbi.nlm.nih.gov/pubmed/32047731
http://dx.doi.org/10.3389/fped.2020.00006
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