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Inhibition Mechanism of Indoleamine 2, 3-Dioxygenase 1 (IDO1) by Amidoxime Derivatives and Its Revelation in Drug Design: Comparative Molecular Dynamics Simulations

For cancer treatment, in addition to the three standard therapies of surgery, chemotherapy, and radiotherapy, immunotherapy has become the fourth internationally-recognized alternative treatment. Indoleamine 2, 3-dioxygenase 1 (IDO1) catalyzes the conversion of tryptophan to kynurenine causing lysin...

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Detalles Bibliográficos
Autores principales:	Liu, Xinyu, Zhang, Yiwen, Duan, Huaichuan, Luo, Qing, Liu, Wei, Liang, Li, Wan, Hua, Chang, Shan, Hu, Jianping, Shi, Hubing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997135/ https://www.ncbi.nlm.nih.gov/pubmed/32047753 http://dx.doi.org/10.3389/fmolb.2019.00164

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