Conformational plasticity of ligand-bound and ternary GPCR complexes studied by (19)F NMR of the β(1)-adrenergic receptor

G-protein-coupled receptors (GPCRs) are allosteric signaling proteins that transmit an extracellular stimulus across the cell membrane. Using (19)F NMR and site-specific labelling, we investigate the response of the cytoplasmic region of transmembrane helices 6 and 7 of the β(1)-adrenergic receptor...

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Detalles Bibliográficos
Autores principales: Frei, J. Niclas, Broadhurst, Richard W., Bostock, Mark J., Solt, Andras, Jones, Andrew J. Y., Gabriel, Florian, Tandale, Aditi, Shrestha, Binesh, Nietlispach, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997182/
https://www.ncbi.nlm.nih.gov/pubmed/32015348
http://dx.doi.org/10.1038/s41467-020-14526-3

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