Locus-specific DNA methylation of Mecp2 promoter leads to autism-like phenotypes in mice

Autism spectrum disorder (ASD) is a neurodevelopmental disease with a strong heritability, but recent evidence suggests that epigenetic dysregulation may also contribute to the pathogenesis of ASD. Especially, increased methylation at the MECP2 promoter and decreased MECP2 expression were observed i...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Zongyang, Liu, Zhen, Mao, Wei, Wang, Xinying, Zheng, Xiaoguo, Chen, Shanshan, Cao, Beibei, Huang, Shisheng, Zhang, Xuliang, Zhou, Tao, Zhang, Yu, Huang, Xingxu, Sun, Qiang, Li, Jia-Da
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997184/
https://www.ncbi.nlm.nih.gov/pubmed/32015323
http://dx.doi.org/10.1038/s41419-020-2290-x

Ejemplares similares

Ejemplares similares