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Loading Amlodipine on Diamond Nanoparticles: A Novel Drug Delivery System

BACKGROUND: Diamond nanoparticles (Nanodiamond) are biocompatible drug delivery platforms with outstanding surface properties. Their passage into the brain has been confirmed previously. Thus, nanodiamond could provide a drug delivery system to shuttle several drugs through the blood-brain barrier (...

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Autores principales: Alawdi, Shawqi H, Eidi, Housam, Safar, Marwa M, Abdel-Wahhab, Mosaad A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997232/
https://www.ncbi.nlm.nih.gov/pubmed/32099339
http://dx.doi.org/10.2147/NSA.S232517
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author Alawdi, Shawqi H
Eidi, Housam
Safar, Marwa M
Abdel-Wahhab, Mosaad A
author_facet Alawdi, Shawqi H
Eidi, Housam
Safar, Marwa M
Abdel-Wahhab, Mosaad A
author_sort Alawdi, Shawqi H
collection PubMed
description BACKGROUND: Diamond nanoparticles (Nanodiamond) are biocompatible drug delivery platforms with outstanding surface properties. Their passage into the brain has been confirmed previously. Thus, nanodiamond could provide a drug delivery system to shuttle several drugs through the blood-brain barrier (BBB) which represents a real challenge for the effective delivery of several drugs into the brain. Amlodipine is a calcium channel blocker that cannot pass through BBB and may elicit neuroprotective effects to reverse calcium-induced excitotoxicity and mitochondrial dysfunction that underlie several neurologic disorders including Alzheimer’s disease and stroke. AIM: The study aimed to investigate the loading of amlodipine on nanodiamond particles. METHODS: Nanodiamond particles were oxidized in a strong oxidizing acidic mixture of sulfuric and nitric acids. Adsorption of amlodipine on nanodiamond particles was achieved in alkaline pH using various concentrations of sodium hydroxide. The loaded amlodipine was determined by high-performance liquid chromatography and confirmed by Fourier transform infrared (FTIR) spectroscopy and transmission electron microscopy. RESULTS: The highest percentage (41%) of loaded amlodipine onto nanodiamond particles was achieved in alkaline medium using 2 mM NaOH at a corresponding pH of 8.5. Also, characteristic FTIR bands of amlodipine and nanodiamond were shown obviously in the nanodiamond–amlodipine conjugates. Moreover, the successful loading of amlodipine on diamond nanoparticles was confirmed by transmission electron microscopy. CONCLUSION: The present study demonstrates the successful loading of amlodipine onto nanodiamond particles. These findings offer a potential for applying diamond nanoparticles as a drug delivery system to shuttle amlodipine into the brain and open the door to deliver other similar drugs into the brain.
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spelling pubmed-69972322020-02-25 Loading Amlodipine on Diamond Nanoparticles: A Novel Drug Delivery System Alawdi, Shawqi H Eidi, Housam Safar, Marwa M Abdel-Wahhab, Mosaad A Nanotechnol Sci Appl Original Research BACKGROUND: Diamond nanoparticles (Nanodiamond) are biocompatible drug delivery platforms with outstanding surface properties. Their passage into the brain has been confirmed previously. Thus, nanodiamond could provide a drug delivery system to shuttle several drugs through the blood-brain barrier (BBB) which represents a real challenge for the effective delivery of several drugs into the brain. Amlodipine is a calcium channel blocker that cannot pass through BBB and may elicit neuroprotective effects to reverse calcium-induced excitotoxicity and mitochondrial dysfunction that underlie several neurologic disorders including Alzheimer’s disease and stroke. AIM: The study aimed to investigate the loading of amlodipine on nanodiamond particles. METHODS: Nanodiamond particles were oxidized in a strong oxidizing acidic mixture of sulfuric and nitric acids. Adsorption of amlodipine on nanodiamond particles was achieved in alkaline pH using various concentrations of sodium hydroxide. The loaded amlodipine was determined by high-performance liquid chromatography and confirmed by Fourier transform infrared (FTIR) spectroscopy and transmission electron microscopy. RESULTS: The highest percentage (41%) of loaded amlodipine onto nanodiamond particles was achieved in alkaline medium using 2 mM NaOH at a corresponding pH of 8.5. Also, characteristic FTIR bands of amlodipine and nanodiamond were shown obviously in the nanodiamond–amlodipine conjugates. Moreover, the successful loading of amlodipine on diamond nanoparticles was confirmed by transmission electron microscopy. CONCLUSION: The present study demonstrates the successful loading of amlodipine onto nanodiamond particles. These findings offer a potential for applying diamond nanoparticles as a drug delivery system to shuttle amlodipine into the brain and open the door to deliver other similar drugs into the brain. Dove 2019-12-31 /pmc/articles/PMC6997232/ /pubmed/32099339 http://dx.doi.org/10.2147/NSA.S232517 Text en © 2019 Alawdi et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Alawdi, Shawqi H
Eidi, Housam
Safar, Marwa M
Abdel-Wahhab, Mosaad A
Loading Amlodipine on Diamond Nanoparticles: A Novel Drug Delivery System
title Loading Amlodipine on Diamond Nanoparticles: A Novel Drug Delivery System
title_full Loading Amlodipine on Diamond Nanoparticles: A Novel Drug Delivery System
title_fullStr Loading Amlodipine on Diamond Nanoparticles: A Novel Drug Delivery System
title_full_unstemmed Loading Amlodipine on Diamond Nanoparticles: A Novel Drug Delivery System
title_short Loading Amlodipine on Diamond Nanoparticles: A Novel Drug Delivery System
title_sort loading amlodipine on diamond nanoparticles: a novel drug delivery system
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997232/
https://www.ncbi.nlm.nih.gov/pubmed/32099339
http://dx.doi.org/10.2147/NSA.S232517
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