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The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea

Rosacea is a chronic inflammatory cutaneous disorder that adversely affects patient's health and quality of life due to the complex course and the need for repeated treatment. The exact molecular mechanisms of rosacea are unclear. Mast cells are innate immune cells that can be found in virtuall...

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Autores principales: Wang, Lian, Wang, Yu-Jia, Hao, Dan, Wen, Xiang, Du, Dan, He, Gu, Jiang, Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997331/
https://www.ncbi.nlm.nih.gov/pubmed/32047752
http://dx.doi.org/10.3389/fmed.2019.00324
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author Wang, Lian
Wang, Yu-Jia
Hao, Dan
Wen, Xiang
Du, Dan
He, Gu
Jiang, Xian
author_facet Wang, Lian
Wang, Yu-Jia
Hao, Dan
Wen, Xiang
Du, Dan
He, Gu
Jiang, Xian
author_sort Wang, Lian
collection PubMed
description Rosacea is a chronic inflammatory cutaneous disorder that adversely affects patient's health and quality of life due to the complex course and the need for repeated treatment. The exact molecular mechanisms of rosacea are unclear. Mast cells are innate immune cells that can be found in virtually all tissues. Recently, increasing evidence has indicated that mast cells have important effects on the pathogenesis of rosacea. In this review article, we describe recent advances of skin mast cells in the development of rosacea. These studies suggested that mast cells can be an important immune cell that connected innate immunity, nerves, and blood vessels in the development of rosacea. Moreover, we review the inhibition of mast cells for the potential treatment of rosacea.
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spelling pubmed-69973312020-02-11 The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea Wang, Lian Wang, Yu-Jia Hao, Dan Wen, Xiang Du, Dan He, Gu Jiang, Xian Front Med (Lausanne) Medicine Rosacea is a chronic inflammatory cutaneous disorder that adversely affects patient's health and quality of life due to the complex course and the need for repeated treatment. The exact molecular mechanisms of rosacea are unclear. Mast cells are innate immune cells that can be found in virtually all tissues. Recently, increasing evidence has indicated that mast cells have important effects on the pathogenesis of rosacea. In this review article, we describe recent advances of skin mast cells in the development of rosacea. These studies suggested that mast cells can be an important immune cell that connected innate immunity, nerves, and blood vessels in the development of rosacea. Moreover, we review the inhibition of mast cells for the potential treatment of rosacea. Frontiers Media S.A. 2020-01-28 /pmc/articles/PMC6997331/ /pubmed/32047752 http://dx.doi.org/10.3389/fmed.2019.00324 Text en Copyright © 2020 Wang, Wang, Hao, Wen, Du, He and Jiang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Wang, Lian
Wang, Yu-Jia
Hao, Dan
Wen, Xiang
Du, Dan
He, Gu
Jiang, Xian
The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea
title The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea
title_full The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea
title_fullStr The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea
title_full_unstemmed The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea
title_short The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea
title_sort theranostics role of mast cells in the pathophysiology of rosacea
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997331/
https://www.ncbi.nlm.nih.gov/pubmed/32047752
http://dx.doi.org/10.3389/fmed.2019.00324
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