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IL-27 Counteracts Neuropathic Pain Development Through Induction of IL-10
Neuroimmune–glia interactions have been implicated in the development of neuropathic pain. Interleukin-27 (IL-27) is a cytokine that presents regulatory activity in inflammatory conditions of the central nervous system. Thus, we hypothesized that IL-27 would participate in the neuropathic pain proce...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997342/ https://www.ncbi.nlm.nih.gov/pubmed/32047492 http://dx.doi.org/10.3389/fimmu.2019.03059 |
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author | Fonseca, Miriam M. Davoli-Ferreira, Marcela Santa-Cecília, Flávia Guimarães, Rafaela M. Oliveira, Francisco F. B. Kusuda, Ricardo Ferreira, David W. Alves-Filho, José C. Cunha, Fernando Q. Cunha, Thiago M. |
author_facet | Fonseca, Miriam M. Davoli-Ferreira, Marcela Santa-Cecília, Flávia Guimarães, Rafaela M. Oliveira, Francisco F. B. Kusuda, Ricardo Ferreira, David W. Alves-Filho, José C. Cunha, Fernando Q. Cunha, Thiago M. |
author_sort | Fonseca, Miriam M. |
collection | PubMed |
description | Neuroimmune–glia interactions have been implicated in the development of neuropathic pain. Interleukin-27 (IL-27) is a cytokine that presents regulatory activity in inflammatory conditions of the central nervous system. Thus, we hypothesized that IL-27 would participate in the neuropathic pain process. Here, we found that neuropathic pain caused by peripheral nerve injury (spared nerve injury model; SNI), was enhanced in IL-27-deficient((−/−)) mice, whereas nociceptive pain is similar to that of wild-type mice. SNI induced an increase in the expression of IL-27 and its receptor subunit (Wsx1) in the sensory ganglia and spinal cord. IL-27 receptor was expressed mainly in resident macrophage, microglia, and astrocytes of the sensory ganglia and spinal cord, respectively. Finally, we identify that the antinociceptive effect of IL-27 was not observed in IL-10(−/−) mice. These results provided evidence that IL-27 is a cytokine produced after peripheral nerve injury that counteracts neuropathic pain development through induction of the antinociceptive cytokine IL-10. In summary, our study unraveled the role of IL-27 as a regulatory cytokine that counteracts the development of neuropathic pain after peripheral nerve damage. In conclusion, they indicate that immunotherapies based on IL-27 could emerge as possible therapeutic approaches for the prevention of neuropathic pain development after peripheral nerve injury. |
format | Online Article Text |
id | pubmed-6997342 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69973422020-02-11 IL-27 Counteracts Neuropathic Pain Development Through Induction of IL-10 Fonseca, Miriam M. Davoli-Ferreira, Marcela Santa-Cecília, Flávia Guimarães, Rafaela M. Oliveira, Francisco F. B. Kusuda, Ricardo Ferreira, David W. Alves-Filho, José C. Cunha, Fernando Q. Cunha, Thiago M. Front Immunol Immunology Neuroimmune–glia interactions have been implicated in the development of neuropathic pain. Interleukin-27 (IL-27) is a cytokine that presents regulatory activity in inflammatory conditions of the central nervous system. Thus, we hypothesized that IL-27 would participate in the neuropathic pain process. Here, we found that neuropathic pain caused by peripheral nerve injury (spared nerve injury model; SNI), was enhanced in IL-27-deficient((−/−)) mice, whereas nociceptive pain is similar to that of wild-type mice. SNI induced an increase in the expression of IL-27 and its receptor subunit (Wsx1) in the sensory ganglia and spinal cord. IL-27 receptor was expressed mainly in resident macrophage, microglia, and astrocytes of the sensory ganglia and spinal cord, respectively. Finally, we identify that the antinociceptive effect of IL-27 was not observed in IL-10(−/−) mice. These results provided evidence that IL-27 is a cytokine produced after peripheral nerve injury that counteracts neuropathic pain development through induction of the antinociceptive cytokine IL-10. In summary, our study unraveled the role of IL-27 as a regulatory cytokine that counteracts the development of neuropathic pain after peripheral nerve damage. In conclusion, they indicate that immunotherapies based on IL-27 could emerge as possible therapeutic approaches for the prevention of neuropathic pain development after peripheral nerve injury. Frontiers Media S.A. 2020-01-28 /pmc/articles/PMC6997342/ /pubmed/32047492 http://dx.doi.org/10.3389/fimmu.2019.03059 Text en Copyright © 2020 Fonseca, Davoli-Ferreira, Santa-Cecília, Guimarães, Oliveira, Kusuda, Ferreira, Alves-Filho, Cunha and Cunha. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Fonseca, Miriam M. Davoli-Ferreira, Marcela Santa-Cecília, Flávia Guimarães, Rafaela M. Oliveira, Francisco F. B. Kusuda, Ricardo Ferreira, David W. Alves-Filho, José C. Cunha, Fernando Q. Cunha, Thiago M. IL-27 Counteracts Neuropathic Pain Development Through Induction of IL-10 |
title | IL-27 Counteracts Neuropathic Pain Development Through Induction of IL-10 |
title_full | IL-27 Counteracts Neuropathic Pain Development Through Induction of IL-10 |
title_fullStr | IL-27 Counteracts Neuropathic Pain Development Through Induction of IL-10 |
title_full_unstemmed | IL-27 Counteracts Neuropathic Pain Development Through Induction of IL-10 |
title_short | IL-27 Counteracts Neuropathic Pain Development Through Induction of IL-10 |
title_sort | il-27 counteracts neuropathic pain development through induction of il-10 |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997342/ https://www.ncbi.nlm.nih.gov/pubmed/32047492 http://dx.doi.org/10.3389/fimmu.2019.03059 |
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