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A peptide derived from the core β-sheet region of TIRAP decoys TLR4 and reduces inflammatory and autoimmune symptoms in murine models

BACKGROUND: TLRs are some of the actively pursued drug-targets in immune disorders. Owing to a recent surge in the cognizance of TLR structural biology and signalling pathways, numerous therapeutic modulators, ranging from low-molecular-weight organic compounds to polypeptides and nucleic acid agent...

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Detalles Bibliográficos
Autores principales:	Achek, Asma, Kwon, Hyuk-Kwon, Patra, Mahesh Chandra, Shah, Masaud, Hong, Riwon, Lee, Wang Hee, Baek, Wook-Young, Choi, Yang Seon, Kim, Gi-Young, Pham, Thuong L.H., Suh, Chang-Hee, Kim, Wook, Hahm, Dae-Hyun, Choi, Sangdun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997517/ https://www.ncbi.nlm.nih.gov/pubmed/32014819 http://dx.doi.org/10.1016/j.ebiom.2020.102645

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