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Age-Related Alterations of White Matter Integrity in Adolescents and Young Adults With Bipolar Disorder

BACKGROUND: Alterations of white matter integrity during adolescence/young adulthood may contribute to the neurodevelopmental pathophysiology of bipolar disorder (BD), but it remains unknown how white matter integrity changes in BD patients during this critical period of brain development. In the pr...

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Autores principales: Ren, Sihua, Chang, Miao, Yin, Zhiyang, Feng, Ruiqi, Wei, Yange, Duan, Jia, Jiang, Xiaowei, Wei, Shengnan, Tang, Yanqing, Wang, Fei, Li, Songbai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997540/
https://www.ncbi.nlm.nih.gov/pubmed/32047447
http://dx.doi.org/10.3389/fpsyt.2019.01010
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author Ren, Sihua
Chang, Miao
Yin, Zhiyang
Feng, Ruiqi
Wei, Yange
Duan, Jia
Jiang, Xiaowei
Wei, Shengnan
Tang, Yanqing
Wang, Fei
Li, Songbai
author_facet Ren, Sihua
Chang, Miao
Yin, Zhiyang
Feng, Ruiqi
Wei, Yange
Duan, Jia
Jiang, Xiaowei
Wei, Shengnan
Tang, Yanqing
Wang, Fei
Li, Songbai
author_sort Ren, Sihua
collection PubMed
description BACKGROUND: Alterations of white matter integrity during adolescence/young adulthood may contribute to the neurodevelopmental pathophysiology of bipolar disorder (BD), but it remains unknown how white matter integrity changes in BD patients during this critical period of brain development. In the present study, we aimed to identify possible age-associated alterations of white matter integrity in adolescents and young adults with BD across the age range of 13–30 years. METHODS: We divided the participants into two groups by age as follows: adolescent group involving individuals of 13–21 years old (39 patients with BD and 39 healthy controls) and young adult group involving individuals of 22–30 years old (47 patients with BD and 47 healthy controls). Diffusion tensor imaging (DTI) was performed in all participants to assess white matter integrity. RESULTS: In the adolescent group, compared to those of healthy controls, fractional anisotropy (FA) values were significantly lower in BD patients in the left inferior longitudinal fasciculus, splenium of the corpus callosum and posterior thalamic radiation. In the young adult group, BD patients showed significantly decreased FA values in the bilateral uncinate fasciculus, genu of the corpus callosum, right anterior limb of internal capsule and fornix compared to healthy controls. White matter impairments changed from the posterior brain to the anterior brain representing a back-to-front spatiotemporal directionality in an age-related pattern. CONCLUSIONS: Our findings provide neuroimaging evidence supporting a back-to-front spatiotemporal directionality of the altered development of white matter integrity associated with age in BD patients during adolescence/young adulthood.
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spelling pubmed-69975402020-02-11 Age-Related Alterations of White Matter Integrity in Adolescents and Young Adults With Bipolar Disorder Ren, Sihua Chang, Miao Yin, Zhiyang Feng, Ruiqi Wei, Yange Duan, Jia Jiang, Xiaowei Wei, Shengnan Tang, Yanqing Wang, Fei Li, Songbai Front Psychiatry Psychiatry BACKGROUND: Alterations of white matter integrity during adolescence/young adulthood may contribute to the neurodevelopmental pathophysiology of bipolar disorder (BD), but it remains unknown how white matter integrity changes in BD patients during this critical period of brain development. In the present study, we aimed to identify possible age-associated alterations of white matter integrity in adolescents and young adults with BD across the age range of 13–30 years. METHODS: We divided the participants into two groups by age as follows: adolescent group involving individuals of 13–21 years old (39 patients with BD and 39 healthy controls) and young adult group involving individuals of 22–30 years old (47 patients with BD and 47 healthy controls). Diffusion tensor imaging (DTI) was performed in all participants to assess white matter integrity. RESULTS: In the adolescent group, compared to those of healthy controls, fractional anisotropy (FA) values were significantly lower in BD patients in the left inferior longitudinal fasciculus, splenium of the corpus callosum and posterior thalamic radiation. In the young adult group, BD patients showed significantly decreased FA values in the bilateral uncinate fasciculus, genu of the corpus callosum, right anterior limb of internal capsule and fornix compared to healthy controls. White matter impairments changed from the posterior brain to the anterior brain representing a back-to-front spatiotemporal directionality in an age-related pattern. CONCLUSIONS: Our findings provide neuroimaging evidence supporting a back-to-front spatiotemporal directionality of the altered development of white matter integrity associated with age in BD patients during adolescence/young adulthood. Frontiers Media S.A. 2020-01-28 /pmc/articles/PMC6997540/ /pubmed/32047447 http://dx.doi.org/10.3389/fpsyt.2019.01010 Text en Copyright © 2020 Ren, Chang, Yin, Feng, Wei, Duan, Jiang, Wei, Tang, Wang and Li http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Ren, Sihua
Chang, Miao
Yin, Zhiyang
Feng, Ruiqi
Wei, Yange
Duan, Jia
Jiang, Xiaowei
Wei, Shengnan
Tang, Yanqing
Wang, Fei
Li, Songbai
Age-Related Alterations of White Matter Integrity in Adolescents and Young Adults With Bipolar Disorder
title Age-Related Alterations of White Matter Integrity in Adolescents and Young Adults With Bipolar Disorder
title_full Age-Related Alterations of White Matter Integrity in Adolescents and Young Adults With Bipolar Disorder
title_fullStr Age-Related Alterations of White Matter Integrity in Adolescents and Young Adults With Bipolar Disorder
title_full_unstemmed Age-Related Alterations of White Matter Integrity in Adolescents and Young Adults With Bipolar Disorder
title_short Age-Related Alterations of White Matter Integrity in Adolescents and Young Adults With Bipolar Disorder
title_sort age-related alterations of white matter integrity in adolescents and young adults with bipolar disorder
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997540/
https://www.ncbi.nlm.nih.gov/pubmed/32047447
http://dx.doi.org/10.3389/fpsyt.2019.01010
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