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The Relationship Between IDH1 Mutation Status and Metabolic Imaging in Nonenhancing Supratentorial Diffuse Gliomas: A (11)C-MET PET Study
PURPOSE: We evaluated the relationship between isocitrate dehydrogenase 1 (IDH1) mutation status and metabolic imaging in patients with nonenhancing supratentorial diffuse gliomas using (11)C-methionine positron emission tomography ((11)C-MET PET). MATERIALS AND METHODS: Between June 2012 and Novemb...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997723/ https://www.ncbi.nlm.nih.gov/pubmed/31889470 http://dx.doi.org/10.1177/1536012119894087 |
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author | Kudulaiti, Nijiati Zhang, Huiwei Qiu, Tianming Lu, Junfeng Aibaidula, Abudumijiti Zhang, Zhengwei Guan, Yihui Zhuang, Dongxiao |
author_facet | Kudulaiti, Nijiati Zhang, Huiwei Qiu, Tianming Lu, Junfeng Aibaidula, Abudumijiti Zhang, Zhengwei Guan, Yihui Zhuang, Dongxiao |
author_sort | Kudulaiti, Nijiati |
collection | PubMed |
description | PURPOSE: We evaluated the relationship between isocitrate dehydrogenase 1 (IDH1) mutation status and metabolic imaging in patients with nonenhancing supratentorial diffuse gliomas using (11)C-methionine positron emission tomography ((11)C-MET PET). MATERIALS AND METHODS: Between June 2012 and November 2017, we enrolled 86 (38 women and 48 men; mean age, 41.9 ± 13.1 years [range, 8-67 years]) patients with newly diagnosed supratentorial diffuse gliomas. All patients underwent preoperative (11)C-MET PET. Tumor samples were obtained and immunohistochemically analyzed for IDH1 mutation status. RESULTS: The mutant and wild-type IDH1 diffuse gliomas had significantly different mean maximum standardized uptake value values (2.73 [95% confidence interval, CI: 2.32-3.16] vs 3.85 [95% CI: 3.22-4.51], respectively; P = .004) and mean tumor-to-background ratio (1.90 [95% CI: 1.65-2.16] vs 2.59 [95% CI: 2.17-3.04], respectively; P = .007). CONCLUSIONS: (11)C-methionine PET can noninvasively evaluate the IDH1 mutation status of patients with nonenhancing supratentorial diffuse gliomas. |
format | Online Article Text |
id | pubmed-6997723 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-69977232020-02-18 The Relationship Between IDH1 Mutation Status and Metabolic Imaging in Nonenhancing Supratentorial Diffuse Gliomas: A (11)C-MET PET Study Kudulaiti, Nijiati Zhang, Huiwei Qiu, Tianming Lu, Junfeng Aibaidula, Abudumijiti Zhang, Zhengwei Guan, Yihui Zhuang, Dongxiao Mol Imaging Research Article PURPOSE: We evaluated the relationship between isocitrate dehydrogenase 1 (IDH1) mutation status and metabolic imaging in patients with nonenhancing supratentorial diffuse gliomas using (11)C-methionine positron emission tomography ((11)C-MET PET). MATERIALS AND METHODS: Between June 2012 and November 2017, we enrolled 86 (38 women and 48 men; mean age, 41.9 ± 13.1 years [range, 8-67 years]) patients with newly diagnosed supratentorial diffuse gliomas. All patients underwent preoperative (11)C-MET PET. Tumor samples were obtained and immunohistochemically analyzed for IDH1 mutation status. RESULTS: The mutant and wild-type IDH1 diffuse gliomas had significantly different mean maximum standardized uptake value values (2.73 [95% confidence interval, CI: 2.32-3.16] vs 3.85 [95% CI: 3.22-4.51], respectively; P = .004) and mean tumor-to-background ratio (1.90 [95% CI: 1.65-2.16] vs 2.59 [95% CI: 2.17-3.04], respectively; P = .007). CONCLUSIONS: (11)C-methionine PET can noninvasively evaluate the IDH1 mutation status of patients with nonenhancing supratentorial diffuse gliomas. SAGE Publications 2019-12-31 /pmc/articles/PMC6997723/ /pubmed/31889470 http://dx.doi.org/10.1177/1536012119894087 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Research Article Kudulaiti, Nijiati Zhang, Huiwei Qiu, Tianming Lu, Junfeng Aibaidula, Abudumijiti Zhang, Zhengwei Guan, Yihui Zhuang, Dongxiao The Relationship Between IDH1 Mutation Status and Metabolic Imaging in Nonenhancing Supratentorial Diffuse Gliomas: A (11)C-MET PET Study |
title | The Relationship Between IDH1 Mutation Status and Metabolic Imaging in Nonenhancing Supratentorial Diffuse Gliomas: A (11)C-MET PET Study |
title_full | The Relationship Between IDH1 Mutation Status and Metabolic Imaging in Nonenhancing Supratentorial Diffuse Gliomas: A (11)C-MET PET Study |
title_fullStr | The Relationship Between IDH1 Mutation Status and Metabolic Imaging in Nonenhancing Supratentorial Diffuse Gliomas: A (11)C-MET PET Study |
title_full_unstemmed | The Relationship Between IDH1 Mutation Status and Metabolic Imaging in Nonenhancing Supratentorial Diffuse Gliomas: A (11)C-MET PET Study |
title_short | The Relationship Between IDH1 Mutation Status and Metabolic Imaging in Nonenhancing Supratentorial Diffuse Gliomas: A (11)C-MET PET Study |
title_sort | relationship between idh1 mutation status and metabolic imaging in nonenhancing supratentorial diffuse gliomas: a (11)c-met pet study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997723/ https://www.ncbi.nlm.nih.gov/pubmed/31889470 http://dx.doi.org/10.1177/1536012119894087 |
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