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A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus

Influenza A virus (IAV) causes significant morbidity and mortality, despite the availability of viral vaccines. The efficacy of live attenuated influenza vaccines (LAIVs) has been especially poor in recent years. One potential reason is that the master donor virus (MDV), on which all LAIVs are based...

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Detalles Bibliográficos
Autores principales:	Smith, Andrew, Rodriguez, Laura, El Ghouayel, Maya, Nogales, Aitor, Chamberlain, Jeffrey M., Sortino, Katherine, Reilly, Emma, Feng, Changyong, Topham, David J., Martínez-Sobrido, Luis, Dewhurst, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Vaccines and Antiviral Agents
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997774/ https://www.ncbi.nlm.nih.gov/pubmed/31748399 http://dx.doi.org/10.1128/JVI.01065-19

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