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Minimally invasive versus open radical cystectomy for bladder cancer: A systematic review and meta-analysis
BACKGROUND: We performed a systematic review and meta-analysis to evaluate the efficacy and safety of minimally invasive radical cystectomy (MIRC) versus open radical cystectomy (ORC) for bladder cancer. METHODS: We searched the EMBASE and MEDLINE databases to identify randomized controlled trials (...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997785/ https://www.ncbi.nlm.nih.gov/pubmed/31638461 http://dx.doi.org/10.1177/0300060519864806 |
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author | Shi, Hongbin Li, Jiangsong Li, Kui Yang, Xiaobo Zhu, Zaisheng Tian, Daxue |
author_facet | Shi, Hongbin Li, Jiangsong Li, Kui Yang, Xiaobo Zhu, Zaisheng Tian, Daxue |
author_sort | Shi, Hongbin |
collection | PubMed |
description | BACKGROUND: We performed a systematic review and meta-analysis to evaluate the efficacy and safety of minimally invasive radical cystectomy (MIRC) versus open radical cystectomy (ORC) for bladder cancer. METHODS: We searched the EMBASE and MEDLINE databases to identify randomized controlled trials (RCTs) of MIRC versus ORC in the treatment of bladder cancer. RESULTS: Eight articles describing nine RCTs (803 patients) were analyzed. No significant differences were found between MIRC and ORC in two oncologic outcomes: the recurrence rate and mortality. Additionally, no significant differences were found in three pathologic outcomes: lymph node yield, positive lymph nodes, and positive surgical margins. With respect to perioperative outcomes, however, MIRC showed a significantly longer operating time, less estimated blood loss, lower blood transfusion rate, shorter time to regular diet, and shorter length of hospital stay than ORC. The incidence of complications was similar between the two techniques. We found no statistically significant differences in the above outcomes between robot-assisted radical cystectomy and ORC or between laparoscopic radical cystectomy and ORC with the exception of the complication rate. CONCLUSIONS: MIRC is an effective and safe surgical approach in the treatment of bladder cancer. However, a large-scale multicenter RCT is needed to confirm these findings. |
format | Online Article Text |
id | pubmed-6997785 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-69977852020-02-18 Minimally invasive versus open radical cystectomy for bladder cancer: A systematic review and meta-analysis Shi, Hongbin Li, Jiangsong Li, Kui Yang, Xiaobo Zhu, Zaisheng Tian, Daxue J Int Med Res Meta-Analysis BACKGROUND: We performed a systematic review and meta-analysis to evaluate the efficacy and safety of minimally invasive radical cystectomy (MIRC) versus open radical cystectomy (ORC) for bladder cancer. METHODS: We searched the EMBASE and MEDLINE databases to identify randomized controlled trials (RCTs) of MIRC versus ORC in the treatment of bladder cancer. RESULTS: Eight articles describing nine RCTs (803 patients) were analyzed. No significant differences were found between MIRC and ORC in two oncologic outcomes: the recurrence rate and mortality. Additionally, no significant differences were found in three pathologic outcomes: lymph node yield, positive lymph nodes, and positive surgical margins. With respect to perioperative outcomes, however, MIRC showed a significantly longer operating time, less estimated blood loss, lower blood transfusion rate, shorter time to regular diet, and shorter length of hospital stay than ORC. The incidence of complications was similar between the two techniques. We found no statistically significant differences in the above outcomes between robot-assisted radical cystectomy and ORC or between laparoscopic radical cystectomy and ORC with the exception of the complication rate. CONCLUSIONS: MIRC is an effective and safe surgical approach in the treatment of bladder cancer. However, a large-scale multicenter RCT is needed to confirm these findings. SAGE Publications 2019-10-22 2019-10 /pmc/articles/PMC6997785/ /pubmed/31638461 http://dx.doi.org/10.1177/0300060519864806 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Meta-Analysis Shi, Hongbin Li, Jiangsong Li, Kui Yang, Xiaobo Zhu, Zaisheng Tian, Daxue Minimally invasive versus open radical cystectomy for bladder cancer: A systematic review and meta-analysis |
title | Minimally invasive versus open radical cystectomy for bladder cancer:
A systematic review and meta-analysis |
title_full | Minimally invasive versus open radical cystectomy for bladder cancer:
A systematic review and meta-analysis |
title_fullStr | Minimally invasive versus open radical cystectomy for bladder cancer:
A systematic review and meta-analysis |
title_full_unstemmed | Minimally invasive versus open radical cystectomy for bladder cancer:
A systematic review and meta-analysis |
title_short | Minimally invasive versus open radical cystectomy for bladder cancer:
A systematic review and meta-analysis |
title_sort | minimally invasive versus open radical cystectomy for bladder cancer:
a systematic review and meta-analysis |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997785/ https://www.ncbi.nlm.nih.gov/pubmed/31638461 http://dx.doi.org/10.1177/0300060519864806 |
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