O-acetylation of typhoid capsular polysaccharide confers polysaccharide rigidity and immunodominance by masking additional epitopes

In this work, we explore the effects of O-acetylation on the physical and immunological characteristics of the WHO International Standards of Vi polysaccharide (Vi) from both Citrobacter freundii and Salmonella enterica serovar Typhi. We find that, although structurally identical according to NMR, t...

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Detalles Bibliográficos
Autores principales: Hitri, Krisztina, Kuttel, Michelle M., De Benedetto, Gianluigi, Lockyer, Kay, Gao, Fang, Hansal, Peter, Rudd, Timothy R., Beamish, Emma, Rijpkema, Sjoerd, Ravenscroft, Neil, Bolgiano, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997886/
https://www.ncbi.nlm.nih.gov/pubmed/31160100
http://dx.doi.org/10.1016/j.vaccine.2019.05.050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997886/
https://www.ncbi.nlm.nih.gov/pubmed/31160100
http://dx.doi.org/10.1016/j.vaccine.2019.05.050

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