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Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone

Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1. The NQO1 bioactivatable agent β-lapachone can target cells with high NQO1 expression but relies in the generation of react...

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Detalles Bibliográficos
Autores principales:	Torrente, Laura, Prieto-Farigua, Nicolas, Falzone, Aimee, Elkins, Cody M., Boothman, David A., Haura, Eric B., DeNicola, Gina M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997906/ https://www.ncbi.nlm.nih.gov/pubmed/32007910 http://dx.doi.org/10.1016/j.redox.2020.101440

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