Allosteric Regulation of Hsp90α’s Activity by Small Molecules Targeting the Middle Domain of the Chaperone

Hsp90 is a target for anti-cancer drug development. Both the conformational events tuned by ATP/ADP and co-chaperones and the chaperoning cycle timing are required for Hsp90's fully functional display. Interfering with either one of the conformational events or the cycle timing will down-regula...

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Detalles Bibliográficos
Autores principales: Zhou, Chen, Zhang, Chi, Zhu, Hongwen, Liu, Zhijun, Su, Haixia, Zhang, Xianglei, Chen, Tingting, Zhong, Yan, Hu, Huifang, Xiong, Muya, Zhou, Hu, Xu, Yechun, Zhang, Ao, Zhang, Naixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997908/
https://www.ncbi.nlm.nih.gov/pubmed/32058968
http://dx.doi.org/10.1016/j.isci.2020.100857

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