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New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
PURPOSE: To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam). METHODS: Wistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998060/ https://www.ncbi.nlm.nih.gov/pubmed/32022101 http://dx.doi.org/10.1590/s0102-865020190120000001 |
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author | Macêdo, Clóvis Ney Pinheiro Braga, Francisco Evanilso Silva Campelo, Ana Paula Bomfim Soares Diniz, Gabriel Maia Lopes, Luiz Gonzaga de França Kubrusly, Marcos Campelo, Marcio Wilker Soares |
author_facet | Macêdo, Clóvis Ney Pinheiro Braga, Francisco Evanilso Silva Campelo, Ana Paula Bomfim Soares Diniz, Gabriel Maia Lopes, Luiz Gonzaga de França Kubrusly, Marcos Campelo, Marcio Wilker Soares |
author_sort | Macêdo, Clóvis Ney Pinheiro |
collection | PubMed |
description | PURPOSE: To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam). METHODS: Wistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of experiments, kidneys were removed for histological study, fractal dimension and lacunarity in all animals. RESULTS: At the histological examination, all animals (six animals – 100 %) in the NSAID group had membrane thickening and other changes (necrosis, acute tubular congestion and vascular congestion); on the other hand, only one animal (16.6 %) of the Rut-bpy group had congestion. The fractal dimension and lacunarity were greater in the control and Rut-bpy group than in NSAIDs group (p<0.05). CONCLUSION: Rut-bpy may prevent renal histological changes in rats caused by meloxicam. |
format | Online Article Text |
id | pubmed-6998060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
record_format | MEDLINE/PubMed |
spelling | pubmed-69980602020-02-18 New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory Macêdo, Clóvis Ney Pinheiro Braga, Francisco Evanilso Silva Campelo, Ana Paula Bomfim Soares Diniz, Gabriel Maia Lopes, Luiz Gonzaga de França Kubrusly, Marcos Campelo, Marcio Wilker Soares Acta Cir Bras Original Article PURPOSE: To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam). METHODS: Wistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of experiments, kidneys were removed for histological study, fractal dimension and lacunarity in all animals. RESULTS: At the histological examination, all animals (six animals – 100 %) in the NSAID group had membrane thickening and other changes (necrosis, acute tubular congestion and vascular congestion); on the other hand, only one animal (16.6 %) of the Rut-bpy group had congestion. The fractal dimension and lacunarity were greater in the control and Rut-bpy group than in NSAIDs group (p<0.05). CONCLUSION: Rut-bpy may prevent renal histological changes in rats caused by meloxicam. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2020-02-03 /pmc/articles/PMC6998060/ /pubmed/32022101 http://dx.doi.org/10.1590/s0102-865020190120000001 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Macêdo, Clóvis Ney Pinheiro Braga, Francisco Evanilso Silva Campelo, Ana Paula Bomfim Soares Diniz, Gabriel Maia Lopes, Luiz Gonzaga de França Kubrusly, Marcos Campelo, Marcio Wilker Soares New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory |
title | New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
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title_full | New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
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title_fullStr | New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
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title_full_unstemmed | New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
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title_short | New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
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title_sort | new metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998060/ https://www.ncbi.nlm.nih.gov/pubmed/32022101 http://dx.doi.org/10.1590/s0102-865020190120000001 |
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