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New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory

PURPOSE: To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam). METHODS: Wistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam...

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Autores principales: Macêdo, Clóvis Ney Pinheiro, Braga, Francisco Evanilso Silva, Campelo, Ana Paula Bomfim Soares, Diniz, Gabriel Maia, Lopes, Luiz Gonzaga de França, Kubrusly, Marcos, Campelo, Marcio Wilker Soares
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998060/
https://www.ncbi.nlm.nih.gov/pubmed/32022101
http://dx.doi.org/10.1590/s0102-865020190120000001
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author Macêdo, Clóvis Ney Pinheiro
Braga, Francisco Evanilso Silva
Campelo, Ana Paula Bomfim Soares
Diniz, Gabriel Maia
Lopes, Luiz Gonzaga de França
Kubrusly, Marcos
Campelo, Marcio Wilker Soares
author_facet Macêdo, Clóvis Ney Pinheiro
Braga, Francisco Evanilso Silva
Campelo, Ana Paula Bomfim Soares
Diniz, Gabriel Maia
Lopes, Luiz Gonzaga de França
Kubrusly, Marcos
Campelo, Marcio Wilker Soares
author_sort Macêdo, Clóvis Ney Pinheiro
collection PubMed
description PURPOSE: To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam). METHODS: Wistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of experiments, kidneys were removed for histological study, fractal dimension and lacunarity in all animals. RESULTS: At the histological examination, all animals (six animals – 100 %) in the NSAID group had membrane thickening and other changes (necrosis, acute tubular congestion and vascular congestion); on the other hand, only one animal (16.6 %) of the Rut-bpy group had congestion. The fractal dimension and lacunarity were greater in the control and Rut-bpy group than in NSAIDs group (p<0.05). CONCLUSION: Rut-bpy may prevent renal histological changes in rats caused by meloxicam.
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spelling pubmed-69980602020-02-18 New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory Macêdo, Clóvis Ney Pinheiro Braga, Francisco Evanilso Silva Campelo, Ana Paula Bomfim Soares Diniz, Gabriel Maia Lopes, Luiz Gonzaga de França Kubrusly, Marcos Campelo, Marcio Wilker Soares Acta Cir Bras Original Article PURPOSE: To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam). METHODS: Wistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of experiments, kidneys were removed for histological study, fractal dimension and lacunarity in all animals. RESULTS: At the histological examination, all animals (six animals – 100 %) in the NSAID group had membrane thickening and other changes (necrosis, acute tubular congestion and vascular congestion); on the other hand, only one animal (16.6 %) of the Rut-bpy group had congestion. The fractal dimension and lacunarity were greater in the control and Rut-bpy group than in NSAIDs group (p<0.05). CONCLUSION: Rut-bpy may prevent renal histological changes in rats caused by meloxicam. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2020-02-03 /pmc/articles/PMC6998060/ /pubmed/32022101 http://dx.doi.org/10.1590/s0102-865020190120000001 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Macêdo, Clóvis Ney Pinheiro
Braga, Francisco Evanilso Silva
Campelo, Ana Paula Bomfim Soares
Diniz, Gabriel Maia
Lopes, Luiz Gonzaga de França
Kubrusly, Marcos
Campelo, Marcio Wilker Soares
New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
title New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
title_full New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
title_fullStr New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
title_full_unstemmed New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
title_short New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
title_sort new metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998060/
https://www.ncbi.nlm.nih.gov/pubmed/32022101
http://dx.doi.org/10.1590/s0102-865020190120000001
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