Cargando…

Metformin improves lipid metabolism and reverses the Warburg effect in a canine model of chronic atrial fibrillation

BACKGROUND: Previous studies demonstrated impaired lipid metabolism and augmented aerobic glycolysis in AF. The authors aimed to investigate whether the use of metformin, an AMPK activator, could reverse this metabolic remodeling in chronic AF and to explore the underlying mechanisms. METHODS: We co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yaozhong, Bai, Fan, Liu, Na, Zhang, Baojian, Qin, Fen, Tu, Tao, Li, Biao, Li, Jiayi, Ma, Yingxu, Ouyang, Feifan, Liu, Qiming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998172/ https://www.ncbi.nlm.nih.gov/pubmed/32013885 http://dx.doi.org/10.1186/s12872-020-01359-7

Ejemplares similares

Metformin regulates lipid metabolism in a canine model of atrial fibrillation through AMPK/PPAR-α/VLCAD pathway
por: Bai, Fan, et al.
Publicado: (2019)

Mendelian Randomization Integrating GWAS, eQTL, and mQTL Data Identified Genes Pleiotropically Associated With Atrial Fibrillation
por: Liu, Yaozhong, et al.
Publicado: (2021)

Metformin regulates adiponectin signalling in epicardial adipose tissue and reduces atrial fibrillation vulnerability
por: Li, Biao, et al.
Publicado: (2020)

Quantitative acetylated proteomics on left atrial appendage tissues revealed atrial energy metabolism and contraction status in patients with valvular heart disease with atrial fibrillation
por: Tu, Tao, et al.
Publicado: (2022)

Comparison between High-Power Short-Duration and Conventional Ablation Strategy in Atrial Fibrillation: An Updated Meta-Analysis
por: Li, Mohan, et al.
Publicado: (2022)

Education and Atrial Fibrillation: Mendelian Randomization Study
por: Liu, Yaozhong, et al.
Publicado: (2022)

Identification and validation of aging-related genes in atrial fibrillation
por: Zhou, Yong, et al.
Publicado: (2023)

Catheter ablation for treatment of patients with atrial fibrillation and heart failure: a meta-analysis of randomized controlled trials
por: Ma, Yingxu, et al.
Publicado: (2018)

Exploring immune related gene signatures and mechanisms linking non alcoholic fatty liver disease to atrial fibrillation through transcriptome data analysis
por: Wu, Keke, et al.
Publicado: (2023)

Longer Leukocyte Telomere Length Increases the Risk of Atrial Fibrillation: A Mendelian Randomization Study
por: Liu, Yaozhong, et al.
Publicado: (2022)

Integrative transcriptomic, proteomic, and machine learning approach to identifying feature genes of atrial fibrillation using atrial samples from patients with valvular heart disease
por: Liu, Yaozhong, et al.
Publicado: (2021)

Identifying ceRNA Networks Associated With the Susceptibility and Persistence of Atrial Fibrillation Through Weighted Gene Co-Expression Network Analysis
por: Liu, Yaozhong, et al.
Publicado: (2021)

Metformin prevents DMH-induced colorectal cancer in diabetic rats by reversing the warburg effect
por: Jia, Yanglei, et al.
Publicado: (2015)

Exosomal miR-27b-3p Derived from Hypoxic Cardiac Microvascular Endothelial Cells Alleviates Rat Myocardial Ischemia/Reperfusion Injury through Inhibiting Oxidative Stress-Induced Pyroptosis via Foxo1/GSDMD Signaling
por: Zhang, Baojian, et al.
Publicado: (2022)

Connexin 43 is involved in the sympathetic atrial fibrillation in canine and canine atrial myocytes
por: Shu, Chenglin, et al.
Publicado: (2017)

Autophagy, Warburg, and Warburg Reverse Effects in Human Cancer
por: Gonzalez, Claudio D., et al.
Publicado: (2014)

Nicotinamide mononucleotide attenuates HIF-1α activation and fibrosis in hypoxic adipose tissue via NAD(+)/SIRT1 axis
por: Wu, Keke, et al.
Publicado: (2023)

The reverse warburg effect in osteosarcoma
por: Sotgia, Federica, et al.
Publicado: (2014)

First in-human robotic rotor ablation for atrial fibrillation
por: Lin, Tina, et al.
Publicado: (2014)

Expression of serum microRNA-155 and its clinical importance in patients with heart failure after myocardial infarction
por: Zhang, Baojian, et al.
Publicado: (2019)

Hydrogen Sulfide Ameliorates Angiotensin II-Induced Atrial Fibrosis Progression to Atrial Fibrillation Through Inhibition of the Warburg Effect and Endoplasmic Reticulum Stress
por: Hu, Heng-Jing, et al.
Publicado: (2021)

New use for an old drug: Metformin and atrial fibrillation
por: Vinciguerra, Manlio, et al.
Publicado: (2022)

Blockade of Exosome Release Suppresses Atrial Fibrillation by Alleviating Atrial Fibrosis in Canines With Prolonged Atrial Pacing
por: Yao, Yajun, et al.
Publicado: (2021)

Patent foramen ovale closure or medical therapy for secondary prevention of cryptogenic stroke: An update meta-analysis of randomized controlled trials
por: Ma, Yingxu, et al.
Publicado: (2018)

Canagliflozin Suppresses Atrial Remodeling in a Canine Atrial Fibrillation Model
por: Nishinarita, Ryo, et al.
Publicado: (2021)

Multi-scale computational study of the Warburg effect, reverse Warburg effect and glutamine addiction in solid tumors
por: Shan, Mengrou, et al.
Publicado: (2018)

Neural substrate of posterior left atrium: A novel modulation for inducibility and remodeling of atrial fibrillation in canine
por: Qin, Mu, et al.
Publicado: (2017)

Beta-blockers for the primary prevention of anthracycline-induced cardiotoxicity: a meta-analysis of randomized controlled trials
por: Ma, Yingxu, et al.
Publicado: (2019)

Progress of Pathogenesis in Pediatric Multifocal Atrial Tachycardia
por: Chen, Huaiyang, et al.
Publicado: (2022)

The reverse Warburg effect is likely to be an Achilles' heel of cancer that can be exploited for cancer therapy
por: Fu, Yaojie, et al.
Publicado: (2017)

High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells
por: Zhu, Songbiao, et al.
Publicado: (2022)

Irbesartan prevents sodium channel remodeling in a canine model of atrial fibrillation
por: Wang, Xuewen, et al.
Publicado: (2018)

Catheter ablation or medical therapy to delay progression of atrial fibrillation: the randomized controlled atrial fibrillation progression trial (ATTEST)
por: Kuck, Karl-Heinz, et al.
Publicado: (2020)

Associations of Visceral Adipose Tissue, Circulating Protein Biomarkers, and Risk of Cardiovascular Diseases: A Mendelian Randomization Analysis
por: Huang, Yunying, et al.
Publicado: (2022)

Left atrial dyssynchrony time measured by tissue Doppler imaging to predict atrial fibrillation recurrences after pulmonary vein isolation
por: Salah, Ahmed, et al.
Publicado: (2015)

Reversible atrial fibrillation following Crotalinae envenomation
por: Quan, Dan, et al.
Publicado: (2017)

SIRT5 functions as a tumor suppressor in renal cell carcinoma by reversing the Warburg effect
por: Yihan, Liu, et al.
Publicado: (2021)

Establishment of a Model of Renal Impairment with Mild Renal Insufficiency Associated with Atrial Fibrillation in Canines
por: Liang, Zhuo, et al.
Publicado: (2014)

Catheter ablation for the treatment of persistent atrial fibrillation: Maintenance of sinus rhythm with left atrial appendage and coronary sinus isolation after multiple ablation procedures
por: Liang, Dong Po, et al.
Publicado: (2015)

P Wave Indices to Predict Atrial Fibrillation Recurrences Post Pulmonary Vein Isolation
por: Salah, Ahmed, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_pl8mvrbe9a3692apc11apd5oji