The enigma of soluble LDLR: could inflammation be the key?

Soluble low-density lipoprotein receptor (sLDLR) is the circulating ectodomain of transmembrane LDLR. Its blood level strongly correlates with that of triglycerides (TG). This correlation has eluded satisfactory explanation. Hypertriglyceridemia and shedding of the ectodomain of many transmembrane r...

Descripción completa

Detalles Bibliográficos
Autores principales: Mbikay, Majambu, Mayne, Janice, Chrétien, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998292/
https://www.ncbi.nlm.nih.gov/pubmed/32014013
http://dx.doi.org/10.1186/s12944-020-1199-9
_version_ 1783493828136665088
author Mbikay, Majambu
Mayne, Janice
Chrétien, Michel
author_facet Mbikay, Majambu
Mayne, Janice
Chrétien, Michel
author_sort Mbikay, Majambu
collection PubMed
description Soluble low-density lipoprotein receptor (sLDLR) is the circulating ectodomain of transmembrane LDLR. Its blood level strongly correlates with that of triglycerides (TG). This correlation has eluded satisfactory explanation. Hypertriglyceridemia and shedding of the ectodomain of many transmembrane receptors often accompany inflammatory states. The shedding mostly occurs through cleavage by a disintegrin-and-metalloproteinase-17 (ADAM-17), an enzyme activated by inflammation. It reduces the cellular uptake of TG-loaded lipoproteins, causing their accumulation in circulation; hence the correlation between plasma sLDLR and TG. Soluble LDLR could become a new surrogate marker of inflammation.
format Online
Article
Text
id pubmed-6998292
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-69982922020-02-05 The enigma of soluble LDLR: could inflammation be the key? Mbikay, Majambu Mayne, Janice Chrétien, Michel Lipids Health Dis Hypothesis Soluble low-density lipoprotein receptor (sLDLR) is the circulating ectodomain of transmembrane LDLR. Its blood level strongly correlates with that of triglycerides (TG). This correlation has eluded satisfactory explanation. Hypertriglyceridemia and shedding of the ectodomain of many transmembrane receptors often accompany inflammatory states. The shedding mostly occurs through cleavage by a disintegrin-and-metalloproteinase-17 (ADAM-17), an enzyme activated by inflammation. It reduces the cellular uptake of TG-loaded lipoproteins, causing their accumulation in circulation; hence the correlation between plasma sLDLR and TG. Soluble LDLR could become a new surrogate marker of inflammation. BioMed Central 2020-02-03 /pmc/articles/PMC6998292/ /pubmed/32014013 http://dx.doi.org/10.1186/s12944-020-1199-9 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Hypothesis
Mbikay, Majambu
Mayne, Janice
Chrétien, Michel
The enigma of soluble LDLR: could inflammation be the key?
title The enigma of soluble LDLR: could inflammation be the key?
title_full The enigma of soluble LDLR: could inflammation be the key?
title_fullStr The enigma of soluble LDLR: could inflammation be the key?
title_full_unstemmed The enigma of soluble LDLR: could inflammation be the key?
title_short The enigma of soluble LDLR: could inflammation be the key?
title_sort enigma of soluble ldlr: could inflammation be the key?
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998292/
https://www.ncbi.nlm.nih.gov/pubmed/32014013
http://dx.doi.org/10.1186/s12944-020-1199-9
work_keys_str_mv AT mbikaymajambu theenigmaofsolubleldlrcouldinflammationbethekey
AT maynejanice theenigmaofsolubleldlrcouldinflammationbethekey
AT chretienmichel theenigmaofsolubleldlrcouldinflammationbethekey
AT mbikaymajambu enigmaofsolubleldlrcouldinflammationbethekey
AT maynejanice enigmaofsolubleldlrcouldinflammationbethekey
AT chretienmichel enigmaofsolubleldlrcouldinflammationbethekey

Ejemplares similares