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Metastatic Brain Choriocarcinoma in a Postmenopausal Woman: A Case Report
Patient: Female, 66-year-old Final Diagnosis: Choriocarcinoma Symptoms: Vaginal bleeding Medication: — Clinical Procedure: — Specialty: Obstetrics and Gynecology OBJECTIVE: Unusual clinical course BACKGROUND: Choriocarcinoma is the most aggressive form of gestational trophoblastic disease and usuall...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998797/ https://www.ncbi.nlm.nih.gov/pubmed/31986128 http://dx.doi.org/10.12659/AJCR.917656 |
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author | Dombrovsky, Inessa Tilden, Hannah R. Aftandilians, Tania Wong, Shirley Stowe, Robert J. |
author_facet | Dombrovsky, Inessa Tilden, Hannah R. Aftandilians, Tania Wong, Shirley Stowe, Robert J. |
author_sort | Dombrovsky, Inessa |
collection | PubMed |
description | Patient: Female, 66-year-old Final Diagnosis: Choriocarcinoma Symptoms: Vaginal bleeding Medication: — Clinical Procedure: — Specialty: Obstetrics and Gynecology OBJECTIVE: Unusual clinical course BACKGROUND: Choriocarcinoma is the most aggressive form of gestational trophoblastic disease and usually occurs in women of childbearing age, most commonly within 1 year after an abnormal pregnancy. Postmenopausal chorio-carcinoma is exceptionally rare and few cases have been described in the literature. CASE REPORT: We present the case of a 66-year-old woman who presented to the Emergency Department with sudden onset of left upper- and lower-extremity weakness. She was found to have a brain mass, which was excised by neurosurgery and found to be a choriocarcinoma. She was then started on standard first-line therapy of EMACO, but was subsequently lost to follow-up. CONCLUSIONS: Postmenopausal choriocarcinoma is rare and there are few case reports in the literature. It is a rare but possibly under-diagnosed metastatic disease in women. At present, a postmenopausal woman without a clear primary tumor should have a pregnancy test performed to rule out choriocarcinoma, as it is readily responsive to therapy. |
format | Online Article Text |
id | pubmed-6998797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69987972020-02-13 Metastatic Brain Choriocarcinoma in a Postmenopausal Woman: A Case Report Dombrovsky, Inessa Tilden, Hannah R. Aftandilians, Tania Wong, Shirley Stowe, Robert J. Am J Case Rep Articles Patient: Female, 66-year-old Final Diagnosis: Choriocarcinoma Symptoms: Vaginal bleeding Medication: — Clinical Procedure: — Specialty: Obstetrics and Gynecology OBJECTIVE: Unusual clinical course BACKGROUND: Choriocarcinoma is the most aggressive form of gestational trophoblastic disease and usually occurs in women of childbearing age, most commonly within 1 year after an abnormal pregnancy. Postmenopausal chorio-carcinoma is exceptionally rare and few cases have been described in the literature. CASE REPORT: We present the case of a 66-year-old woman who presented to the Emergency Department with sudden onset of left upper- and lower-extremity weakness. She was found to have a brain mass, which was excised by neurosurgery and found to be a choriocarcinoma. She was then started on standard first-line therapy of EMACO, but was subsequently lost to follow-up. CONCLUSIONS: Postmenopausal choriocarcinoma is rare and there are few case reports in the literature. It is a rare but possibly under-diagnosed metastatic disease in women. At present, a postmenopausal woman without a clear primary tumor should have a pregnancy test performed to rule out choriocarcinoma, as it is readily responsive to therapy. International Scientific Literature, Inc. 2020-01-27 /pmc/articles/PMC6998797/ /pubmed/31986128 http://dx.doi.org/10.12659/AJCR.917656 Text en © Am J Case Rep, 2020 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Articles Dombrovsky, Inessa Tilden, Hannah R. Aftandilians, Tania Wong, Shirley Stowe, Robert J. Metastatic Brain Choriocarcinoma in a Postmenopausal Woman: A Case Report |
title | Metastatic Brain Choriocarcinoma in a Postmenopausal Woman: A Case Report |
title_full | Metastatic Brain Choriocarcinoma in a Postmenopausal Woman: A Case Report |
title_fullStr | Metastatic Brain Choriocarcinoma in a Postmenopausal Woman: A Case Report |
title_full_unstemmed | Metastatic Brain Choriocarcinoma in a Postmenopausal Woman: A Case Report |
title_short | Metastatic Brain Choriocarcinoma in a Postmenopausal Woman: A Case Report |
title_sort | metastatic brain choriocarcinoma in a postmenopausal woman: a case report |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998797/ https://www.ncbi.nlm.nih.gov/pubmed/31986128 http://dx.doi.org/10.12659/AJCR.917656 |
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