Engineered disulfide bonds improve thermostability and activity of L‐isoleucine hydroxylase for efficient 4‐HIL production in Bacillus subtilis 168

4‐Hydroxyisoleucine, a promising drug, has mainly been applied in the clinical treatment of type 2 diabetes in the pharmaceutical industry. l‐Isoleucine hydroxylase specifically converts l‐Ile to 4‐hydroxyisoleucine. However, due to its poor thermostability, the industrial production of 4‐hydroxyiso...

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Detalles Bibliográficos
Autores principales: Qiao, Zhina, Xu, Meijuan, Shao, Minglong, Zhao, Youxi, Long, Mengfei, Yang, Taowei, Zhang, Xian, Yang, Shangtian, Nakanishi, Hideki, Rao, Zhiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999076/
https://www.ncbi.nlm.nih.gov/pubmed/32625042
http://dx.doi.org/10.1002/elsc.201900090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999076/
https://www.ncbi.nlm.nih.gov/pubmed/32625042
http://dx.doi.org/10.1002/elsc.201900090

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