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Statistical distributions commonly used in measurement uncertainty in laboratory medicine

Uncertainty is an inseparable part of all types of measurement. Recently, the International Organization for Standardization (ISO) released a new standard (ISO 20914) on how to calculate measurement uncertainty (MU) in laboratory medicine. This standard can be regarded as the beginning of a new era...

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Autores principales: Coskun, Abdurrahman, Oosterhuis, Wytze P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Croatian Society of Medical Biochemistry and Laboratory Medicine 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999182/
https://www.ncbi.nlm.nih.gov/pubmed/32063728
http://dx.doi.org/10.11613/BM.2020.010101
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author Coskun, Abdurrahman
Oosterhuis, Wytze P.
author_facet Coskun, Abdurrahman
Oosterhuis, Wytze P.
author_sort Coskun, Abdurrahman
collection PubMed
description Uncertainty is an inseparable part of all types of measurement. Recently, the International Organization for Standardization (ISO) released a new standard (ISO 20914) on how to calculate measurement uncertainty (MU) in laboratory medicine. This standard can be regarded as the beginning of a new era in laboratory medicine. Measurement uncertainty comprises various components and is used to calculate the total uncertainty. All components must be expressed in standard deviation (SD) and then combined. However, the characteristics of these components are not the same; some are expressed as SD, while others are expressed as a ± b, such as the purity of the reagents. All non-SD variables must be transformed into SD, which requires a detailed knowledge of common statistical distributions used in the calculation of MU. Here, the main statistical distributions used in MU calculation are briefly summarized.
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spelling pubmed-69991822020-02-15 Statistical distributions commonly used in measurement uncertainty in laboratory medicine Coskun, Abdurrahman Oosterhuis, Wytze P. Biochem Med (Zagreb) Lessons in Biostatistics Uncertainty is an inseparable part of all types of measurement. Recently, the International Organization for Standardization (ISO) released a new standard (ISO 20914) on how to calculate measurement uncertainty (MU) in laboratory medicine. This standard can be regarded as the beginning of a new era in laboratory medicine. Measurement uncertainty comprises various components and is used to calculate the total uncertainty. All components must be expressed in standard deviation (SD) and then combined. However, the characteristics of these components are not the same; some are expressed as SD, while others are expressed as a ± b, such as the purity of the reagents. All non-SD variables must be transformed into SD, which requires a detailed knowledge of common statistical distributions used in the calculation of MU. Here, the main statistical distributions used in MU calculation are briefly summarized. Croatian Society of Medical Biochemistry and Laboratory Medicine 2020-02-15 2020-02-15 /pmc/articles/PMC6999182/ /pubmed/32063728 http://dx.doi.org/10.11613/BM.2020.010101 Text en Croatian Society of Medical Biochemistry and Laboratory Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Lessons in Biostatistics
Coskun, Abdurrahman
Oosterhuis, Wytze P.
Statistical distributions commonly used in measurement uncertainty in laboratory medicine
title Statistical distributions commonly used in measurement uncertainty in laboratory medicine
title_full Statistical distributions commonly used in measurement uncertainty in laboratory medicine
title_fullStr Statistical distributions commonly used in measurement uncertainty in laboratory medicine
title_full_unstemmed Statistical distributions commonly used in measurement uncertainty in laboratory medicine
title_short Statistical distributions commonly used in measurement uncertainty in laboratory medicine
title_sort statistical distributions commonly used in measurement uncertainty in laboratory medicine
topic Lessons in Biostatistics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999182/
https://www.ncbi.nlm.nih.gov/pubmed/32063728
http://dx.doi.org/10.11613/BM.2020.010101
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