Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome

Adaptor protein (AP) complexes mediate key sorting decisions in the cell through selective incorporation of transmembrane proteins into vesicles. Little is known of the roles of AP-4, despite its loss of function leading to a severe early onset neurological disorder, AP-4 deficiency syndrome. Here w...

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Detalles Bibliográficos
Autores principales: Ivankovic, Davor, Drew, James, Lesept, Flavie, White, Ian J., López Doménech, Guillermo, Tooze, Sharon A., Kittler, Josef T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999640/
https://www.ncbi.nlm.nih.gov/pubmed/31142229
http://dx.doi.org/10.1080/15548627.2019.1615302

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