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Lung Cancer Staging and Associated Genetic and Epigenetic Events

The first step in treating lung cancer is to establish the stage of the disease, which in turn determines the treatment options and prognosis of the patient. Many factors are involved in lung cancer staging, but all involve anatomical information. However, new approaches, mainly those based on the m...

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Autores principales: Kim, Dohun, Lee, You-Soub, Kim, Duk-Hwan, Bae, Suk-Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999714/
https://www.ncbi.nlm.nih.gov/pubmed/31999917
http://dx.doi.org/10.14348/molcells.2020.2246
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author Kim, Dohun
Lee, You-Soub
Kim, Duk-Hwan
Bae, Suk-Chul
author_facet Kim, Dohun
Lee, You-Soub
Kim, Duk-Hwan
Bae, Suk-Chul
author_sort Kim, Dohun
collection PubMed
description The first step in treating lung cancer is to establish the stage of the disease, which in turn determines the treatment options and prognosis of the patient. Many factors are involved in lung cancer staging, but all involve anatomical information. However, new approaches, mainly those based on the molecular biology of cancer, have recently changed the paradigm for lung cancer treatment and have not yet been incorporated into staging. In a group of patients of the same stage who receive the same treatment, some may experience unexpected recurrence or metastasis, largely because current staging methods do not reflect the findings of molecular biological studies. In this review, we provide a brief summary of the latest research on lung cancer staging and the molecular events associated with carcinogenesis. We hope that this paper will serve as a bridge between clinicians and basic researchers and aid in our understanding of lung cancer.
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spelling pubmed-69997142020-02-12 Lung Cancer Staging and Associated Genetic and Epigenetic Events Kim, Dohun Lee, You-Soub Kim, Duk-Hwan Bae, Suk-Chul Mol Cells Minireview The first step in treating lung cancer is to establish the stage of the disease, which in turn determines the treatment options and prognosis of the patient. Many factors are involved in lung cancer staging, but all involve anatomical information. However, new approaches, mainly those based on the molecular biology of cancer, have recently changed the paradigm for lung cancer treatment and have not yet been incorporated into staging. In a group of patients of the same stage who receive the same treatment, some may experience unexpected recurrence or metastasis, largely because current staging methods do not reflect the findings of molecular biological studies. In this review, we provide a brief summary of the latest research on lung cancer staging and the molecular events associated with carcinogenesis. We hope that this paper will serve as a bridge between clinicians and basic researchers and aid in our understanding of lung cancer. Korean Society for Molecular and Cellular Biology 2020-01 2020-01-17 /pmc/articles/PMC6999714/ /pubmed/31999917 http://dx.doi.org/10.14348/molcells.2020.2246 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.
spellingShingle Minireview
Kim, Dohun
Lee, You-Soub
Kim, Duk-Hwan
Bae, Suk-Chul
Lung Cancer Staging and Associated Genetic and Epigenetic Events
title Lung Cancer Staging and Associated Genetic and Epigenetic Events
title_full Lung Cancer Staging and Associated Genetic and Epigenetic Events
title_fullStr Lung Cancer Staging and Associated Genetic and Epigenetic Events
title_full_unstemmed Lung Cancer Staging and Associated Genetic and Epigenetic Events
title_short Lung Cancer Staging and Associated Genetic and Epigenetic Events
title_sort lung cancer staging and associated genetic and epigenetic events
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999714/
https://www.ncbi.nlm.nih.gov/pubmed/31999917
http://dx.doi.org/10.14348/molcells.2020.2246
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