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Peripheral inflammatory biomarkers in Alzheimer’s disease: a brief review
Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. The AD pathophysiology entails chronic inflammation involving innate immune cells including microglia, astrocytes, and other peripheral blood...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society for Biochemistry and Molecular Biology
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999828/ https://www.ncbi.nlm.nih.gov/pubmed/31865964 http://dx.doi.org/10.5483/BMBRep.2020.53.1.309 |
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author | Park, Jong-Chan Han, Sun-Ho Mook-Jung, Inhee |
author_facet | Park, Jong-Chan Han, Sun-Ho Mook-Jung, Inhee |
author_sort | Park, Jong-Chan |
collection | PubMed |
description | Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. The AD pathophysiology entails chronic inflammation involving innate immune cells including microglia, astrocytes, and other peripheral blood cells. Inflammatory mediators such as cytokines and complements are also linked to AD pathogenesis. Despite increasing evidence supporting the association between abnormal inflammation and AD, no well-established inflammatory biomarkers are currently available for AD. Since many reports have shown that abnormal inflammation precedes the outbreak of the disease, non-invasive and readily available peripheral inflammatory biomarkers should be considered as possible biomarkers for early diagnosis of AD. In this mini-review, we introduce the peripheral biomarker candidates related to abnormal inflammation in AD and discuss their possible molecular mechanisms. Furthermore, we also summarize the current state of inflammatory biomarker research in clinical practice and molecular diagnostics. We believe this review will provide new insights into biomarker candidates for the early diagnosis of AD with systemic relevance to inflammation during AD pathogenesis. |
format | Online Article Text |
id | pubmed-6999828 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Korean Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-69998282020-02-12 Peripheral inflammatory biomarkers in Alzheimer’s disease: a brief review Park, Jong-Chan Han, Sun-Ho Mook-Jung, Inhee BMB Rep Invited Mini Review Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. The AD pathophysiology entails chronic inflammation involving innate immune cells including microglia, astrocytes, and other peripheral blood cells. Inflammatory mediators such as cytokines and complements are also linked to AD pathogenesis. Despite increasing evidence supporting the association between abnormal inflammation and AD, no well-established inflammatory biomarkers are currently available for AD. Since many reports have shown that abnormal inflammation precedes the outbreak of the disease, non-invasive and readily available peripheral inflammatory biomarkers should be considered as possible biomarkers for early diagnosis of AD. In this mini-review, we introduce the peripheral biomarker candidates related to abnormal inflammation in AD and discuss their possible molecular mechanisms. Furthermore, we also summarize the current state of inflammatory biomarker research in clinical practice and molecular diagnostics. We believe this review will provide new insights into biomarker candidates for the early diagnosis of AD with systemic relevance to inflammation during AD pathogenesis. Korean Society for Biochemistry and Molecular Biology 2020-01 2020-01-31 /pmc/articles/PMC6999828/ /pubmed/31865964 http://dx.doi.org/10.5483/BMBRep.2020.53.1.309 Text en Copyright © 2020 by the The Korean Society for Biochemistry and Molecular Biology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Mini Review Park, Jong-Chan Han, Sun-Ho Mook-Jung, Inhee Peripheral inflammatory biomarkers in Alzheimer’s disease: a brief review |
title | Peripheral inflammatory biomarkers in Alzheimer’s disease: a brief review |
title_full | Peripheral inflammatory biomarkers in Alzheimer’s disease: a brief review |
title_fullStr | Peripheral inflammatory biomarkers in Alzheimer’s disease: a brief review |
title_full_unstemmed | Peripheral inflammatory biomarkers in Alzheimer’s disease: a brief review |
title_short | Peripheral inflammatory biomarkers in Alzheimer’s disease: a brief review |
title_sort | peripheral inflammatory biomarkers in alzheimer’s disease: a brief review |
topic | Invited Mini Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999828/ https://www.ncbi.nlm.nih.gov/pubmed/31865964 http://dx.doi.org/10.5483/BMBRep.2020.53.1.309 |
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