Investigation of the effect of salt additives in Protein L affinity chromatography for the purification of tandem single-chain variable fragment bispecific antibodies

Tandem single-chain variable fragment (scFv) bispecific antibodies (bsAb) are one of the most promising bsAb formats reported thus far. Yet, because of their increased aggregation propensity, high impurity content due to low expression level, smaller size and lack of the Fc region, it is challenging...

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Detalles Bibliográficos
Autores principales: Chen, Serene W., Tan, Darryl, Yang, Yuan Sheng, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999846/
https://www.ncbi.nlm.nih.gov/pubmed/31983280
http://dx.doi.org/10.1080/19420862.2020.1718440

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