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Role of brain imaging in disorders of brain–gut interaction: a Rome Working Team Report
Imaging of the living human brain is a powerful tool to probe the interactions between brain, gut and microbiome in health and in disorders of brain–gut interactions, in particular IBS. While altered signals from the viscera contribute to clinical symptoms, the brain integrates these interoceptive s...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999847/ https://www.ncbi.nlm.nih.gov/pubmed/31175206 http://dx.doi.org/10.1136/gutjnl-2019-318308 |
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author | Mayer, Emeran A Labus, Jennifer Aziz, Qasim Tracey, Irene Kilpatrick, Lisa Elsenbruch, Sigrid Schweinhardt, Petra Van Oudenhove, Lukas Borsook, David |
author_facet | Mayer, Emeran A Labus, Jennifer Aziz, Qasim Tracey, Irene Kilpatrick, Lisa Elsenbruch, Sigrid Schweinhardt, Petra Van Oudenhove, Lukas Borsook, David |
author_sort | Mayer, Emeran A |
collection | PubMed |
description | Imaging of the living human brain is a powerful tool to probe the interactions between brain, gut and microbiome in health and in disorders of brain–gut interactions, in particular IBS. While altered signals from the viscera contribute to clinical symptoms, the brain integrates these interoceptive signals with emotional, cognitive and memory related inputs in a non-linear fashion to produce symptoms. Tremendous progress has occurred in the development of new imaging techniques that look at structural, functional and metabolic properties of brain regions and networks. Standardisation in image acquisition and advances in computational approaches has made it possible to study large data sets of imaging studies, identify network properties and integrate them with non-imaging data. These approaches are beginning to generate brain signatures in IBS that share some features with those obtained in other often overlapping chronic pain disorders such as urological pelvic pain syndromes and vulvodynia, suggesting shared mechanisms. Despite this progress, the identification of preclinical vulnerability factors and outcome predictors has been slow. To overcome current obstacles, the creation of consortia and the generation of standardised multisite repositories for brain imaging and metadata from multisite studies are required. |
format | Online Article Text |
id | pubmed-6999847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
record_format | MEDLINE/PubMed |
spelling | pubmed-69998472020-02-04 Role of brain imaging in disorders of brain–gut interaction: a Rome Working Team Report Mayer, Emeran A Labus, Jennifer Aziz, Qasim Tracey, Irene Kilpatrick, Lisa Elsenbruch, Sigrid Schweinhardt, Petra Van Oudenhove, Lukas Borsook, David Gut Article Imaging of the living human brain is a powerful tool to probe the interactions between brain, gut and microbiome in health and in disorders of brain–gut interactions, in particular IBS. While altered signals from the viscera contribute to clinical symptoms, the brain integrates these interoceptive signals with emotional, cognitive and memory related inputs in a non-linear fashion to produce symptoms. Tremendous progress has occurred in the development of new imaging techniques that look at structural, functional and metabolic properties of brain regions and networks. Standardisation in image acquisition and advances in computational approaches has made it possible to study large data sets of imaging studies, identify network properties and integrate them with non-imaging data. These approaches are beginning to generate brain signatures in IBS that share some features with those obtained in other often overlapping chronic pain disorders such as urological pelvic pain syndromes and vulvodynia, suggesting shared mechanisms. Despite this progress, the identification of preclinical vulnerability factors and outcome predictors has been slow. To overcome current obstacles, the creation of consortia and the generation of standardised multisite repositories for brain imaging and metadata from multisite studies are required. 2019-06-07 2019-09 /pmc/articles/PMC6999847/ /pubmed/31175206 http://dx.doi.org/10.1136/gutjnl-2019-318308 Text en Open access This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Article Mayer, Emeran A Labus, Jennifer Aziz, Qasim Tracey, Irene Kilpatrick, Lisa Elsenbruch, Sigrid Schweinhardt, Petra Van Oudenhove, Lukas Borsook, David Role of brain imaging in disorders of brain–gut interaction: a Rome Working Team Report |
title | Role of brain imaging in disorders of brain–gut interaction: a Rome Working Team Report |
title_full | Role of brain imaging in disorders of brain–gut interaction: a Rome Working Team Report |
title_fullStr | Role of brain imaging in disorders of brain–gut interaction: a Rome Working Team Report |
title_full_unstemmed | Role of brain imaging in disorders of brain–gut interaction: a Rome Working Team Report |
title_short | Role of brain imaging in disorders of brain–gut interaction: a Rome Working Team Report |
title_sort | role of brain imaging in disorders of brain–gut interaction: a rome working team report |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999847/ https://www.ncbi.nlm.nih.gov/pubmed/31175206 http://dx.doi.org/10.1136/gutjnl-2019-318308 |
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