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Jmjd1c is dispensable for healthy adult hematopoiesis and Jak2(V617F)-driven myeloproliferative disease initiation in mice

The histone demethylase JMJD1C is overexpressed in patients with myeloproliferative neoplasms (MPNs) and has been implicated in leukemic stem cell function of MLL-AF9 and HOXA9-driven leukemia. In the emerging field of histone demethylase inhibitors, JMJD1C therefore became a potential target. Deple...

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Detalles Bibliográficos
Autores principales:	Staehle, Hans F., Heinemann, Johannes, Gruender, Albert, Omlor, Anne M., Pahl, Heike Luise, Jutzi, Jonas Samuel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999878/ https://www.ncbi.nlm.nih.gov/pubmed/32017785 http://dx.doi.org/10.1371/journal.pone.0228362

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