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Multiple regions of E6AP (UBE3A) contribute to interaction with papillomavirus E6 proteins and the activation of ubiquitin ligase activity

The HECT domain E3 ubiquitin ligase E6AP (UBE3A) is critical for the development of human papillomavirus (HPV) associated cancers, the neurodevelopment disorder Angelman Syndrome, and some cases of autism spectrum disorders. How E6AP recognizes its cellular targets and how its ubiquitin ligase activ...

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Detalles Bibliográficos
Autores principales:	Drews, Camille M., Brimer, Nicole, Vande Pol, Scott B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999913/ https://www.ncbi.nlm.nih.gov/pubmed/31971989 http://dx.doi.org/10.1371/journal.ppat.1008295

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