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Prolactin response to antipsychotics: An inpatient study
BACKGROUND: Antipsychotic medication, stress, gender, and age are factors that influence prolactin levels in patients with psychosis. The aim of the study was to investigate the level of prolactin response to antipsychotic treatment in acute patients, taking into account the total duration of psycho...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999917/ https://www.ncbi.nlm.nih.gov/pubmed/32017792 http://dx.doi.org/10.1371/journal.pone.0228648 |
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author | Dehelean, Liana Romosan, Ana-Maria Papava, Ion Bredicean, Cristina Ana Dumitrascu, Victor Ursoniu, Sorin Romosan, Radu-Stefan |
author_facet | Dehelean, Liana Romosan, Ana-Maria Papava, Ion Bredicean, Cristina Ana Dumitrascu, Victor Ursoniu, Sorin Romosan, Radu-Stefan |
author_sort | Dehelean, Liana |
collection | PubMed |
description | BACKGROUND: Antipsychotic medication, stress, gender, and age are factors that influence prolactin levels in patients with psychosis. The aim of the study was to investigate the level of prolactin response to antipsychotic treatment in acute patients, taking into account the total duration of psychosis. METHODS AND FINDINGS: The study was conducted on 170 acute patients with schizophrenia spectrum disorders and bipolar disorder. Subjects were divided into three subgroups according to the duration of the psychosis (less than 5 years, between 5 and 10 years and more than 10 years of disorder duration). The initial prolactin response under antipsychotic treatment was measured, while the severity of the psychiatric symptoms was assessed with the BPRS (Brief Psychiatric Rating Scale). Hyperprolactinemia was found in 120 (70.6%) patients, amongst which 80 (66.7%) were females and 40 (33.3%) were males. The average increase in prolactinemia was 2.46 times the maximum value in women, and 1.59 times in men. Gender (β = 0.27, p<0.0001), type of antipsychotic medication according to potency of inducing hyperprolactinemia (β = -0.23, p<0.003), and the duration of psychosis over 10 years (β = -0.15, p = 0.04) significantly predicted prolactin levels, when age, diagnosis, antipsychotic category (conventional/atypical/combinations of antipsychotics), and BPRS total scores were controlled for. CONCLUSIONS AND RELEVANCE: Prolactin levels in patients treated with antipsychotic medication appeared to depend on patients’ gender, on the type of antipsychotic medication according to potency of inducing hyperprolactinemia, and on the duration of the psychosis. An increase in prolactin levels was associated with female gender, while the use of prolactin sparing antipsychotics and a duration of psychosis over 10 years were associated with lower prolactin levels. |
format | Online Article Text |
id | pubmed-6999917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-69999172020-02-18 Prolactin response to antipsychotics: An inpatient study Dehelean, Liana Romosan, Ana-Maria Papava, Ion Bredicean, Cristina Ana Dumitrascu, Victor Ursoniu, Sorin Romosan, Radu-Stefan PLoS One Research Article BACKGROUND: Antipsychotic medication, stress, gender, and age are factors that influence prolactin levels in patients with psychosis. The aim of the study was to investigate the level of prolactin response to antipsychotic treatment in acute patients, taking into account the total duration of psychosis. METHODS AND FINDINGS: The study was conducted on 170 acute patients with schizophrenia spectrum disorders and bipolar disorder. Subjects were divided into three subgroups according to the duration of the psychosis (less than 5 years, between 5 and 10 years and more than 10 years of disorder duration). The initial prolactin response under antipsychotic treatment was measured, while the severity of the psychiatric symptoms was assessed with the BPRS (Brief Psychiatric Rating Scale). Hyperprolactinemia was found in 120 (70.6%) patients, amongst which 80 (66.7%) were females and 40 (33.3%) were males. The average increase in prolactinemia was 2.46 times the maximum value in women, and 1.59 times in men. Gender (β = 0.27, p<0.0001), type of antipsychotic medication according to potency of inducing hyperprolactinemia (β = -0.23, p<0.003), and the duration of psychosis over 10 years (β = -0.15, p = 0.04) significantly predicted prolactin levels, when age, diagnosis, antipsychotic category (conventional/atypical/combinations of antipsychotics), and BPRS total scores were controlled for. CONCLUSIONS AND RELEVANCE: Prolactin levels in patients treated with antipsychotic medication appeared to depend on patients’ gender, on the type of antipsychotic medication according to potency of inducing hyperprolactinemia, and on the duration of the psychosis. An increase in prolactin levels was associated with female gender, while the use of prolactin sparing antipsychotics and a duration of psychosis over 10 years were associated with lower prolactin levels. Public Library of Science 2020-02-04 /pmc/articles/PMC6999917/ /pubmed/32017792 http://dx.doi.org/10.1371/journal.pone.0228648 Text en © 2020 Dehelean et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Dehelean, Liana Romosan, Ana-Maria Papava, Ion Bredicean, Cristina Ana Dumitrascu, Victor Ursoniu, Sorin Romosan, Radu-Stefan Prolactin response to antipsychotics: An inpatient study |
title | Prolactin response to antipsychotics: An inpatient study |
title_full | Prolactin response to antipsychotics: An inpatient study |
title_fullStr | Prolactin response to antipsychotics: An inpatient study |
title_full_unstemmed | Prolactin response to antipsychotics: An inpatient study |
title_short | Prolactin response to antipsychotics: An inpatient study |
title_sort | prolactin response to antipsychotics: an inpatient study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999917/ https://www.ncbi.nlm.nih.gov/pubmed/32017792 http://dx.doi.org/10.1371/journal.pone.0228648 |
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