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APRIL and sTACI could be predictors of multiorgan dysfunction syndrome in sepsis
Although the role of B cells in sepsis immunoregulation has become an interesting topic, there is lack of data on the role of B cell function regulators in prediction of multiorgan dysfunction syndrome (MODS). The aim of this study was to evaluate the prognostic value of A Proliferation Inducing Lig...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Taylor & Francis
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000195/ https://www.ncbi.nlm.nih.gov/pubmed/29781374 http://dx.doi.org/10.1080/21505594.2018.1462636 |
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author | Lendak, Dajana F. Mihajlović, Dunja M. Novakov-Mikić, Aleksandra S. Boban, Jasmina M. Ubavić, Milan Brkić, Snežana V. |
author_facet | Lendak, Dajana F. Mihajlović, Dunja M. Novakov-Mikić, Aleksandra S. Boban, Jasmina M. Ubavić, Milan Brkić, Snežana V. |
author_sort | Lendak, Dajana F. |
collection | PubMed |
description | Although the role of B cells in sepsis immunoregulation has become an interesting topic, there is lack of data on the role of B cell function regulators in prediction of multiorgan dysfunction syndrome (MODS). The aim of this study was to evaluate the prognostic value of A Proliferation Inducing Ligand (APRIL) and soluble Transmembrane Activator and CAML Interactor Protein (sTACI), the main B cell function regulators, in prediction of MODS development within the first 48 h after admission to intensive care unit, among septic patients. We included 112 patients with sepsis, treated at Clinic for Infectious Diseases and Emergency Center, Clinical Center of Vojvodina, Novi Sad, Serbia. Plasma concentrations of APRIL and sTACI were determined at the admission and potential development of MODS was confirmed in the first 48 h. Concentrations of APRIL (p = 0.003) and sTACI (p<0.001) were higher in patients who developed MODS (n = 30). ROC curve analysis showed that AUC for sTACI (AUC = 0.764) was greater than that for procalcitonin (AUC = 0.719) and APRIL (AUC = 0.673) in MODS development prediction. Multivariate regression analysis showed that sTACI, as an anti-inflammatory biomarker stimulating the apoptosis of B cells, was the only independent predictor of MODS, beside SOFA score. Elevated level of sTACI could be the alarm for the increased B cell apoptosis and development of immune paralysis. Including these biomarkers into predictive scores specific for septic patients may potentially improve their sensitivity and specificity. Measurement of their concentrations dynamics could contribute to better assessment of sepsis evolution and timely introduction of immunomodulatory therapy. |
format | Online Article Text |
id | pubmed-7000195 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-70001952020-02-19 APRIL and sTACI could be predictors of multiorgan dysfunction syndrome in sepsis Lendak, Dajana F. Mihajlović, Dunja M. Novakov-Mikić, Aleksandra S. Boban, Jasmina M. Ubavić, Milan Brkić, Snežana V. Virulence Letter Although the role of B cells in sepsis immunoregulation has become an interesting topic, there is lack of data on the role of B cell function regulators in prediction of multiorgan dysfunction syndrome (MODS). The aim of this study was to evaluate the prognostic value of A Proliferation Inducing Ligand (APRIL) and soluble Transmembrane Activator and CAML Interactor Protein (sTACI), the main B cell function regulators, in prediction of MODS development within the first 48 h after admission to intensive care unit, among septic patients. We included 112 patients with sepsis, treated at Clinic for Infectious Diseases and Emergency Center, Clinical Center of Vojvodina, Novi Sad, Serbia. Plasma concentrations of APRIL and sTACI were determined at the admission and potential development of MODS was confirmed in the first 48 h. Concentrations of APRIL (p = 0.003) and sTACI (p<0.001) were higher in patients who developed MODS (n = 30). ROC curve analysis showed that AUC for sTACI (AUC = 0.764) was greater than that for procalcitonin (AUC = 0.719) and APRIL (AUC = 0.673) in MODS development prediction. Multivariate regression analysis showed that sTACI, as an anti-inflammatory biomarker stimulating the apoptosis of B cells, was the only independent predictor of MODS, beside SOFA score. Elevated level of sTACI could be the alarm for the increased B cell apoptosis and development of immune paralysis. Including these biomarkers into predictive scores specific for septic patients may potentially improve their sensitivity and specificity. Measurement of their concentrations dynamics could contribute to better assessment of sepsis evolution and timely introduction of immunomodulatory therapy. Taylor & Francis 2018-05-23 /pmc/articles/PMC7000195/ /pubmed/29781374 http://dx.doi.org/10.1080/21505594.2018.1462636 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Letter Lendak, Dajana F. Mihajlović, Dunja M. Novakov-Mikić, Aleksandra S. Boban, Jasmina M. Ubavić, Milan Brkić, Snežana V. APRIL and sTACI could be predictors of multiorgan dysfunction syndrome in sepsis |
title | APRIL and sTACI could be predictors of multiorgan dysfunction syndrome in sepsis |
title_full | APRIL and sTACI could be predictors of multiorgan dysfunction syndrome in sepsis |
title_fullStr | APRIL and sTACI could be predictors of multiorgan dysfunction syndrome in sepsis |
title_full_unstemmed | APRIL and sTACI could be predictors of multiorgan dysfunction syndrome in sepsis |
title_short | APRIL and sTACI could be predictors of multiorgan dysfunction syndrome in sepsis |
title_sort | april and staci could be predictors of multiorgan dysfunction syndrome in sepsis |
topic | Letter |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000195/ https://www.ncbi.nlm.nih.gov/pubmed/29781374 http://dx.doi.org/10.1080/21505594.2018.1462636 |
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