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Rank orders and signed interactions in evolutionary biology

Rank orders have been studied in evolutionary biology for almost a hundred years. Constraints on the order in which mutations accumulate are known from cancer drug treatment, and order constraints for species invasions are important in ecology. However, current theory on rank orders in biology is so...

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Autor principal: Crona, Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000213/
https://www.ncbi.nlm.nih.gov/pubmed/31934856
http://dx.doi.org/10.7554/eLife.51004
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author Crona, Kristina
author_facet Crona, Kristina
author_sort Crona, Kristina
collection PubMed
description Rank orders have been studied in evolutionary biology for almost a hundred years. Constraints on the order in which mutations accumulate are known from cancer drug treatment, and order constraints for species invasions are important in ecology. However, current theory on rank orders in biology is somewhat fragmented. Here, we show how our previous work on inferring genetic interactions from comparative fitness data (Crona et al., 2017) is related to an influential approach to rank orders based on sign epistasis. Our approach depends on order perturbations that indicate interactions. We apply our results to malaria parasites and find that order perturbations beyond sign epistasis are prevalent in the antimalarial drug-resistance landscape. This finding agrees with the observation that reversed evolution back to the ancestral type is difficult. Another application concerns the adaptation of bacteria to a methanol environment.
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spelling pubmed-70002132020-02-06 Rank orders and signed interactions in evolutionary biology Crona, Kristina eLife Evolutionary Biology Rank orders have been studied in evolutionary biology for almost a hundred years. Constraints on the order in which mutations accumulate are known from cancer drug treatment, and order constraints for species invasions are important in ecology. However, current theory on rank orders in biology is somewhat fragmented. Here, we show how our previous work on inferring genetic interactions from comparative fitness data (Crona et al., 2017) is related to an influential approach to rank orders based on sign epistasis. Our approach depends on order perturbations that indicate interactions. We apply our results to malaria parasites and find that order perturbations beyond sign epistasis are prevalent in the antimalarial drug-resistance landscape. This finding agrees with the observation that reversed evolution back to the ancestral type is difficult. Another application concerns the adaptation of bacteria to a methanol environment. eLife Sciences Publications, Ltd 2020-01-14 /pmc/articles/PMC7000213/ /pubmed/31934856 http://dx.doi.org/10.7554/eLife.51004 Text en © 2020, Crona http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Evolutionary Biology
Crona, Kristina
Rank orders and signed interactions in evolutionary biology
title Rank orders and signed interactions in evolutionary biology
title_full Rank orders and signed interactions in evolutionary biology
title_fullStr Rank orders and signed interactions in evolutionary biology
title_full_unstemmed Rank orders and signed interactions in evolutionary biology
title_short Rank orders and signed interactions in evolutionary biology
title_sort rank orders and signed interactions in evolutionary biology
topic Evolutionary Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000213/
https://www.ncbi.nlm.nih.gov/pubmed/31934856
http://dx.doi.org/10.7554/eLife.51004
work_keys_str_mv AT cronakristina rankordersandsignedinteractionsinevolutionarybiology