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Cdh1-mediated Skp2 degradation by dioscin reprogrammes aerobic glycolysis and inhibits colorectal cancer cells growth

BACKGROUND: The F-box protein S-phase kinase-associated protein 2 (Skp2) is overexpressed and correlated with poor prognosis in human malignancies, including colorectal cancer (CRC). METHODS: A natural product library was used for natural compound screening through glycolysis analysis. The expressio...

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Detalles Bibliográficos
Autores principales:	Zhou, Li, Yu, Xinfang, Li, Ming, Gong, Guanghui, Liu, Wenbin, Li, Tian, Zuo, Huilan, Li, Wei, Gao, Feng, Liu, Haidan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000337/ https://www.ncbi.nlm.nih.gov/pubmed/31806563 http://dx.doi.org/10.1016/j.ebiom.2019.11.031

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