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Novel Na(+)/Ca(2+) Exchanger Inhibitor ORM-10962 Supports Coupled Function of Funny-Current and Na(+)/Ca(2+) Exchanger in Pacemaking of Rabbit Sinus Node Tissue

BACKGROUND AND PURPOSE: The exact mechanism of spontaneous pacemaking is not fully understood. Recent results suggest tight cooperation between intracellular Ca(2+) handling and sarcolemmal ion channels. An important player of this crosstalk is the Na(+)/Ca(2+) exchanger (NCX), however, direct pharm...

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Detalles Bibliográficos
Autores principales:	Kohajda, Zsófia, Tóth, Noémi, Szlovák, Jozefina, Loewe, Axel, Bitay, Gergő, Gazdag, Péter, Prorok, János, Jost, Norbert, Levijoki, Jouko, Pollesello, Piero, Papp, Julius Gy., Varró, András, Nagy, Norbert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000430/ https://www.ncbi.nlm.nih.gov/pubmed/32063850 http://dx.doi.org/10.3389/fphar.2019.01632

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