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Rapamycin and hydroxychloroquine combination alters macrophage polarization and sensitizes glioblastoma to immune checkpoint inhibitors

INTRODUCTION: The failure of immune checkpoint inhibitor (ICPi) on glioblastoma (GBM) treatment underscores the need for improving therapeutic strategy. We aimed to change tumor associated macrophage (TAM) from M2 type (anti-inflammatory) to M1 (pro-inflammatory) type to increase the therapeutic res...

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Detalles Bibliográficos
Autores principales:	Hsu, Sanford P. C., Chen, Yi-Ching, Chiang, Hsin-Chien, Huang, Yi-Chun, Huang, Cheng-Chung, Wang, Hsin-Ell, Wang, Yu-Shang, Chi, Kwan-Hwa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2020
Materias:	Laboratory Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000510/ https://www.ncbi.nlm.nih.gov/pubmed/32020472 http://dx.doi.org/10.1007/s11060-019-03360-3

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