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Tracking regional brain growth up to age 13 in children born term and very preterm

Serial regional brain growth from the newborn period to adolescence has not been described. Here, we measured regional brain growth in 216 very preterm (VP) and 45 full-term (FT) children. Brain MRI was performed at term-equivalent age, 7 and 13 years in 82 regions. Brain volumes increased between t...

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Autores principales: Thompson, Deanne K., Matthews, Lillian G., Alexander, Bonnie, Lee, Katherine J., Kelly, Claire E., Adamson, Chris L., Hunt, Rod W., Cheong, Jeanie L. Y., Spencer-Smith, Megan, Neil, Jeffrey J., Seal, Marc L., Inder, Terrie E., Doyle, Lex W., Anderson, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000691/
https://www.ncbi.nlm.nih.gov/pubmed/32019924
http://dx.doi.org/10.1038/s41467-020-14334-9
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author Thompson, Deanne K.
Matthews, Lillian G.
Alexander, Bonnie
Lee, Katherine J.
Kelly, Claire E.
Adamson, Chris L.
Hunt, Rod W.
Cheong, Jeanie L. Y.
Spencer-Smith, Megan
Neil, Jeffrey J.
Seal, Marc L.
Inder, Terrie E.
Doyle, Lex W.
Anderson, Peter J.
author_facet Thompson, Deanne K.
Matthews, Lillian G.
Alexander, Bonnie
Lee, Katherine J.
Kelly, Claire E.
Adamson, Chris L.
Hunt, Rod W.
Cheong, Jeanie L. Y.
Spencer-Smith, Megan
Neil, Jeffrey J.
Seal, Marc L.
Inder, Terrie E.
Doyle, Lex W.
Anderson, Peter J.
author_sort Thompson, Deanne K.
collection PubMed
description Serial regional brain growth from the newborn period to adolescence has not been described. Here, we measured regional brain growth in 216 very preterm (VP) and 45 full-term (FT) children. Brain MRI was performed at term-equivalent age, 7 and 13 years in 82 regions. Brain volumes increased between term-equivalent and 7 years, with faster growth in the FT than VP group. Perinatal brain abnormality was associated with less increase in brain volume between term-equivalent and 7 years in the VP group. Between 7 and 13 years, volumes were relatively stable, with some subcortical and cortical regions increasing while others reduced. Notably, VP infants continued to lag, with overall brain size generally less than that of FT peers at 13 years. Parieto–frontal growth, mainly between 7 and 13 years in FT children, was associated with higher intelligence at 13 years. This study improves understanding of typical and atypical regional brain growth.
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spelling pubmed-70006912020-02-06 Tracking regional brain growth up to age 13 in children born term and very preterm Thompson, Deanne K. Matthews, Lillian G. Alexander, Bonnie Lee, Katherine J. Kelly, Claire E. Adamson, Chris L. Hunt, Rod W. Cheong, Jeanie L. Y. Spencer-Smith, Megan Neil, Jeffrey J. Seal, Marc L. Inder, Terrie E. Doyle, Lex W. Anderson, Peter J. Nat Commun Article Serial regional brain growth from the newborn period to adolescence has not been described. Here, we measured regional brain growth in 216 very preterm (VP) and 45 full-term (FT) children. Brain MRI was performed at term-equivalent age, 7 and 13 years in 82 regions. Brain volumes increased between term-equivalent and 7 years, with faster growth in the FT than VP group. Perinatal brain abnormality was associated with less increase in brain volume between term-equivalent and 7 years in the VP group. Between 7 and 13 years, volumes were relatively stable, with some subcortical and cortical regions increasing while others reduced. Notably, VP infants continued to lag, with overall brain size generally less than that of FT peers at 13 years. Parieto–frontal growth, mainly between 7 and 13 years in FT children, was associated with higher intelligence at 13 years. This study improves understanding of typical and atypical regional brain growth. Nature Publishing Group UK 2020-02-04 /pmc/articles/PMC7000691/ /pubmed/32019924 http://dx.doi.org/10.1038/s41467-020-14334-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Thompson, Deanne K.
Matthews, Lillian G.
Alexander, Bonnie
Lee, Katherine J.
Kelly, Claire E.
Adamson, Chris L.
Hunt, Rod W.
Cheong, Jeanie L. Y.
Spencer-Smith, Megan
Neil, Jeffrey J.
Seal, Marc L.
Inder, Terrie E.
Doyle, Lex W.
Anderson, Peter J.
Tracking regional brain growth up to age 13 in children born term and very preterm
title Tracking regional brain growth up to age 13 in children born term and very preterm
title_full Tracking regional brain growth up to age 13 in children born term and very preterm
title_fullStr Tracking regional brain growth up to age 13 in children born term and very preterm
title_full_unstemmed Tracking regional brain growth up to age 13 in children born term and very preterm
title_short Tracking regional brain growth up to age 13 in children born term and very preterm
title_sort tracking regional brain growth up to age 13 in children born term and very preterm
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000691/
https://www.ncbi.nlm.nih.gov/pubmed/32019924
http://dx.doi.org/10.1038/s41467-020-14334-9
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