Apoptotic cell-derived exosomes: messages from dying cells

Apoptosis, a type of programmed cell death that plays a key role in both healthy and pathological conditions, releases extracellular vesicles such as apoptotic bodies and microvesicles, but exosome release due to apoptosis is not yet commonly accepted. Here, the reports demonstrating the presence of...

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Autores principales: Kakarla, Ramesh, Hur, Jaehark, Kim, Yeon Ji, Kim, Jaeyoung, Chwae, Yong-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000698/
https://www.ncbi.nlm.nih.gov/pubmed/31915368
http://dx.doi.org/10.1038/s12276-019-0362-8
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author Kakarla, Ramesh
Hur, Jaehark
Kim, Yeon Ji
Kim, Jaeyoung
Chwae, Yong-Joon
author_facet Kakarla, Ramesh
Hur, Jaehark
Kim, Yeon Ji
Kim, Jaeyoung
Chwae, Yong-Joon
author_sort Kakarla, Ramesh
collection PubMed
description Apoptosis, a type of programmed cell death that plays a key role in both healthy and pathological conditions, releases extracellular vesicles such as apoptotic bodies and microvesicles, but exosome release due to apoptosis is not yet commonly accepted. Here, the reports demonstrating the presence of apoptotic exosomes and their roles in inflammation and immune responses are summarized, together with a general summary of apoptosis and extracellular vesicles. In conclusion, apoptosis is not just a ‘silent’ type of cell death but an active form of communication from dying cells to live cells through exosomes.
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spelling pubmed-70006982020-02-12 Apoptotic cell-derived exosomes: messages from dying cells Kakarla, Ramesh Hur, Jaehark Kim, Yeon Ji Kim, Jaeyoung Chwae, Yong-Joon Exp Mol Med Review Article Apoptosis, a type of programmed cell death that plays a key role in both healthy and pathological conditions, releases extracellular vesicles such as apoptotic bodies and microvesicles, but exosome release due to apoptosis is not yet commonly accepted. Here, the reports demonstrating the presence of apoptotic exosomes and their roles in inflammation and immune responses are summarized, together with a general summary of apoptosis and extracellular vesicles. In conclusion, apoptosis is not just a ‘silent’ type of cell death but an active form of communication from dying cells to live cells through exosomes. Nature Publishing Group UK 2020-01-09 /pmc/articles/PMC7000698/ /pubmed/31915368 http://dx.doi.org/10.1038/s12276-019-0362-8 Text en © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Kakarla, Ramesh
Hur, Jaehark
Kim, Yeon Ji
Kim, Jaeyoung
Chwae, Yong-Joon
Apoptotic cell-derived exosomes: messages from dying cells
title Apoptotic cell-derived exosomes: messages from dying cells
title_full Apoptotic cell-derived exosomes: messages from dying cells
title_fullStr Apoptotic cell-derived exosomes: messages from dying cells
title_full_unstemmed Apoptotic cell-derived exosomes: messages from dying cells
title_short Apoptotic cell-derived exosomes: messages from dying cells
title_sort apoptotic cell-derived exosomes: messages from dying cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000698/
https://www.ncbi.nlm.nih.gov/pubmed/31915368
http://dx.doi.org/10.1038/s12276-019-0362-8
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