A kinetic method for measuring agonist efficacy and ligand bias using high resolution biosensors and a kinetic data analysis framework

The kinetics/dynamics of signaling are of increasing value for G-protein-coupled receptor therapeutic development, including spatiotemporal signaling and the kinetic context of biased agonism. Effective application of signaling kinetics to developing new therapeutics requires reliable kinetic assays...

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Detalles Bibliográficos
Autores principales: Hoare, Sam R. J., Tewson, Paul H., Quinn, Anne Marie, Hughes, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000712/
https://www.ncbi.nlm.nih.gov/pubmed/32019973
http://dx.doi.org/10.1038/s41598-020-58421-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000712/
https://www.ncbi.nlm.nih.gov/pubmed/32019973
http://dx.doi.org/10.1038/s41598-020-58421-9

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