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Genotype–phenotype correlation in BRCA1/2 mutation-associated pancreatic cancer
Pancreatic cancers occurring in carriers of a pathogenic germline alteration in BRCA1/2 (gBRCA1/2) are assumed to demonstrate homologous recombination repair deficiency (HRD), associated with sensitivity to platinum-based chemotherapy and synthetic lethality with PARP inhibitors (PARPi). However, pr...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000729/ https://www.ncbi.nlm.nih.gov/pubmed/31787750 http://dx.doi.org/10.1038/s41416-019-0645-9 |