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Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR
Epistasis emerges when the effects of an amino acid depend on the identities of interacting residues. This phenomenon shapes fitness landscapes, which have the power to reveal evolutionary paths and inform evolution of desired functions. However, there is a need for easily implemented, high-throughp...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000732/ https://www.ncbi.nlm.nih.gov/pubmed/32019920 http://dx.doi.org/10.1038/s41467-020-14495-7 |