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Epigenetics and In Utero Acquired Predisposition to Metabolic Disease
Epidemiological evidence has shown an association between prenatal malnutrition and a higher risk of developing metabolic disease in adult life. An inadequate intrauterine milieu affects both growth and development, leading to a permanent programming of endocrine and metabolic functions. Programming...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000755/ https://www.ncbi.nlm.nih.gov/pubmed/32082357 http://dx.doi.org/10.3389/fgene.2019.01270 |
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author | Deodati, Annalisa Inzaghi, Elena Cianfarani, Stefano |
author_facet | Deodati, Annalisa Inzaghi, Elena Cianfarani, Stefano |
author_sort | Deodati, Annalisa |
collection | PubMed |
description | Epidemiological evidence has shown an association between prenatal malnutrition and a higher risk of developing metabolic disease in adult life. An inadequate intrauterine milieu affects both growth and development, leading to a permanent programming of endocrine and metabolic functions. Programming may be due to the epigenetic modification of genes implicated in the regulation of key metabolic mechanisms, including DNA methylation, histone modifications, and microRNAs (miRNAs). The expression of miRNAs in organs that play a key role in metabolism is influenced by in utero programming, as demonstrated by both experimental and human studies. miRNAs modulate multiple pathways such as insulin signaling, immune responses, adipokine function, lipid metabolism, and food intake. Liver is one of the main target organs of programming, undergoing structural, functional, and epigenetic changes following the exposure to a suboptimal intrauterine environment. The focus of this review is to provide an overview of the effects of exposure to an adverse in utero milieu on epigenome with a focus on the molecular mechanisms involved in liver programming. |
format | Online Article Text |
id | pubmed-7000755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70007552020-02-20 Epigenetics and In Utero Acquired Predisposition to Metabolic Disease Deodati, Annalisa Inzaghi, Elena Cianfarani, Stefano Front Genet Genetics Epidemiological evidence has shown an association between prenatal malnutrition and a higher risk of developing metabolic disease in adult life. An inadequate intrauterine milieu affects both growth and development, leading to a permanent programming of endocrine and metabolic functions. Programming may be due to the epigenetic modification of genes implicated in the regulation of key metabolic mechanisms, including DNA methylation, histone modifications, and microRNAs (miRNAs). The expression of miRNAs in organs that play a key role in metabolism is influenced by in utero programming, as demonstrated by both experimental and human studies. miRNAs modulate multiple pathways such as insulin signaling, immune responses, adipokine function, lipid metabolism, and food intake. Liver is one of the main target organs of programming, undergoing structural, functional, and epigenetic changes following the exposure to a suboptimal intrauterine environment. The focus of this review is to provide an overview of the effects of exposure to an adverse in utero milieu on epigenome with a focus on the molecular mechanisms involved in liver programming. Frontiers Media S.A. 2020-01-29 /pmc/articles/PMC7000755/ /pubmed/32082357 http://dx.doi.org/10.3389/fgene.2019.01270 Text en Copyright © 2020 Deodati, Inzaghi and Cianfarani http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Deodati, Annalisa Inzaghi, Elena Cianfarani, Stefano Epigenetics and In Utero Acquired Predisposition to Metabolic Disease |
title | Epigenetics and In Utero Acquired Predisposition to Metabolic Disease |
title_full | Epigenetics and In Utero Acquired Predisposition to Metabolic Disease |
title_fullStr | Epigenetics and In Utero Acquired Predisposition to Metabolic Disease |
title_full_unstemmed | Epigenetics and In Utero Acquired Predisposition to Metabolic Disease |
title_short | Epigenetics and In Utero Acquired Predisposition to Metabolic Disease |
title_sort | epigenetics and in utero acquired predisposition to metabolic disease |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000755/ https://www.ncbi.nlm.nih.gov/pubmed/32082357 http://dx.doi.org/10.3389/fgene.2019.01270 |
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