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Transmembrane domain-mediated Lck association underlies bystander and costimulatory ICOS signaling

The B7-family inducible costimulator (ICOS) activates phosphoinositide-3 kinase (PI3K) and augments calcium mobilization triggered by the T-cell receptor (TCR). We surprisingly found that the entire cytoplasmic domain of ICOS is dispensable for its costimulation of calcium mobilization. This costimu...

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Detalles Bibliográficos
Autores principales:	Wan, Zurong, Shao, Xingxing, Ji, Xingyu, Dong, Lihui, Wei, Jiacheng, Xiong, Zhuqing, Liu, Wanli, Qi, Hai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000777/ https://www.ncbi.nlm.nih.gov/pubmed/30523347 http://dx.doi.org/10.1038/s41423-018-0183-z

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