DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation

Approximately 10% of human colorectal cancer (CRC) are associated with activated BRAFV600E mutation, typically in absence of APC mutation and often associated with a CpG island methylator (CIMP) phenotype. To protect from cancer, normal intestinal epithelial cells respond to oncogenic BRAFV600E by a...

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Detalles Bibliográficos
Autores principales: MacKenzie, Douglas J., Robertson, Neil A., Rather, Iqbal, Reid, Claire, Sendzikaite, Gintare, Cruickshanks, Hazel, McBryan, Tony, Hodges, Andrew, Pritchard, Catrin, Blyth, Karen, Adams, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000804/
https://www.ncbi.nlm.nih.gov/pubmed/32058953
http://dx.doi.org/10.1016/j.isci.2020.100838

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